Results 141 to 150 of about 798,589 (237)

An Out‐of‐Place Etiology: Recognizing FMR1 Premutation in the Memory Clinic

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The FMR1 gene premutation (55–200 CGG repeats) is usually associated with a wide range of symptoms and phenotypes within the Fragile X‐tremor/ataxia syndrome (FXTAS), but may also manifest as predominant or isolated cognitive decline. We describe three male patients referred for progressive cognitive impairment and behavioral changes. Standard
Guido Greco, Caterina Motta, Enrica Marchionni, Maria Rosaria D'Apice, Carlangelo Carrese, Giuseppe Novelli, Alessandro Martorana, Chiara Giuseppina Bonomi   +7 more
wiley   +1 more source

The Radiation Impact of Solar Energetic Particle Events on the Moon: A Statistical Study Using Data‐Based Modeling Results

Space Weather
The Moon lacks a global magnetic field and atmosphere, leaving its surface been directly exposed to high‐energy cosmic radiation. Sporadic Solar Particle Events are sources of a significant radiation exposure, potentially posing serious threats to the ...
Bailiang Liu, Jingnan Guo, Yubao Wang, Mikhail I. Dobynde   +3 more
doaj   +1 more source

A Multiple Model Based Approach for Deep Space Power System Fault Diagnosis [PDF]

Improving protection and health management capabilities onboard the electrical power system (EPS) for spacecraft is essential for ensuring safe and reliable conditions for deep space human exploration.
Carbone, Marc A., Csank, Jeffrey T., Follo, Jeffrey C., Muscatello, Matthew J., Tomko, Brian J.   +4 more
core   +1 more source

Remote Monitoring in Myasthenia Gravis: Exploring Symptom Variability

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is a rare, autoimmune disorder characterized by fluctuating muscle weakness and potential life‐threatening crises. While continuous specialized care is essential, access barriers often delay timely interventions. To address this, we developed MyaLink, a telemedical platform for MG patients.
Maike Stein, Maximilian Mönch, Meret Herdick, Frauke Stascheit, Sarah Hoffmann, Hannah Preßler, Philipp Mergenthaler, Carla Dusemund, Paolo Doksani, Haoqi Sun, Pushpa Narayanaswami, Andreas Meisel, Lea Gerischer, Sophie Lehnerer   +13 more
wiley   +1 more source

Development of a Prediction Model for Progression Risk in High‐Grade Gliomas Based on Habitat Radiomics and Pathomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To investigate the value of constructing models based on habitat radiomics and pathomics for predicting the risk of progression in high‐grade gliomas. Methods This study conducted a retrospective analysis of preoperative magnetic resonance (MR) images and pathological sections from 72 patients diagnosed with high‐grade gliomas (52 ...
Yuchen Zhu, Yuxi Gong, Weilin Xu, Xingjian Sun, Gefei Jiang, Lei Qiu, Kexin Shi, Mengxing Wu, Yinjiao Fei, Jinling Yuan, Jinyan Luo, Yurong Li, Yuandong Cao, Minhong Pan, Shu Zhou   +14 more
wiley   +1 more source

Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu, Yinjiao Fei, Jiaxuan Ding, Kexin Shi, Jinyan Luo, Yuchen Zhu, Xingjian Sun, Gefei Jiang, Yuandong Cao, Weilin Xu, Shu Zhou   +10 more
wiley   +1 more source

NASA's Space Launch System: Secondary Payload Accommodations in Block 1 and Beyond [PDF]

Launching from pad 39B at Kennedy Space Center no earlier than December 2019, NASA's Space Launch System (SLS) will send the Orion crew vehicle to a distant retrograde lunar orbit in order to test and validate the new systems developed for SLS, Orion and
Gardner, Terrie, Robinson, Kimberly F., Schorr, Andrew A.   +2 more
core   +1 more source

Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito, Chiara Meneghini, Alice Galli, Luca Gallo, Pierfrancesco Mitrotti, Paola Dimartino, Marianna Inglese, Cinzia Zatti, Alessandro Lupini, Andrea Pilotto, Alessandro Padovani, Micol Avenali, Enza Maria Valente, Cristina Tassorelli, Silvia P. Caminiti   +14 more
wiley   +1 more source

Specific Immunologic Countermeasure Protocol for Deep-Space Exploration Missions. [PDF]

Front Immunol, 2019
Makedonas G, Mehta S, Choukèr A, Simpson RJ, Marshall G, Orange JS, Aunon-Chancellor S, Smith SM, Zwart SR, Stowe RP, Heer M, Ponomarev S, Whitmire A, Frippiat JP, Douglas GL, Krieger SS, Lorenzi H, Buchheim JI, Ginsburg GS, Ott CM, Downs M, Pierson D, Baecker N, Sams C, Crucian B.   +24 more
europepmc   +1 more source

Challenges to Health During Deep Space Exploration Missions [PDF]

Long duration missions outside of low Earth orbit will present unique challenges to the maintenance of human health. Stressors with physiologic and psychological impacts are inherent in exploration missions, including reduced gravity, increased radiation,
Huff, J., Leveton, L., Norsk, P., Shah, R., Watkins, S.   +4 more
core   +1 more source