Results 91 to 100 of about 699,270 (266)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

The Hindu Kush slab break-off as revealed by deep structure and crustal deformation. [PDF]

open access: yesNat Commun, 2021
Kufner SK   +10 more
europepmc   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

基于体波成像的张渤地震带低速异常深部来源分析

open access: yesDizhen xuebao
为探讨张渤地震带的低速异常与大同火山和渤海湾下方的低速异常的关系,及其幔源物质来源,本文收集了华北地区范围内固定台站和流动台站记录的远震地震事件,应用有限频体波层析成像方法,获得了包含大同火山和渤海湾等构造的0—800 km深度、0.5°×0.5°的P波三维速度结构,同时结合作者之前近震层析成像结果的深度解析,分析了张渤地震带地壳及上地幔低速异常特征,进一步揭示了张渤地震带低速异常幔源物质上涌的深部来源。研究显示华北地区地壳上地幔主要存在西部大同火山下方低速异常和东部的渤海湾下方的低速异常 ...
Qiyan Yang, Qingju Wu
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

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