Results 101 to 110 of about 16,427 (233)
Detection of CWD prions in urine and saliva of deer by transgenic mouse bioassay.
PLoS ONE, 2009 Chronic wasting disease (CWD) is a prion disease affecting captive and free-ranging cervids (e.g. deer, elk, and moose). The mechanisms of CWD transmission are poorly understood, though bodily fluids are thought to play an important role.
Nicholas J Haley +4 more
doaj +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend In lowland mammals that ascend to high elevation, hypoxia‐induced changes in the pulmonary circulation can give rise to hypoxic pulmonary hypertension (HPH) and associated right‐ventricle (RV) hypertrophy. Andean mice with broad elevational ranges have greater heart mass relative to body size at higher elevations, but they ...
Naim M. Bautista +9 more
wiley +1 more source
Mitochondrial physiology in cardiac muscle of deer mice native to high altitude
The Journal of Physiology, EarlyView.Abstract figure legend High‐altitude deer mice exhibited evolved changes in mitochondrial energy metabolism and reactive oxygen species (ROS) management that may support cardiac performance under cold hypoxic conditions. High‐altitude mice had increased activity of lactate dehydrogenase (LDH) in the heart, probably enhancing the capacity for lactate ...
Ranim Saleem +3 more
wiley +1 more source
, 2011 Bartonella infections are common in rodents. From 1994 to 2006, longitudinal studies of a rodent community, consisting mainly of deer mice ( Peromyscus maniculatus ), were conducted in southwestern Colorado to study hantaviruses ...
J. Jeffrey Root +4 more
core +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend The influence of haemoglobin–O2 affinity on aerobic capacity in hypoxia has been contentious. Many high‐altitude natives have greater haemoglobin–O2 affinity (lower P50, the O2 pressure at 50% haemoglobin saturation) than their low‐altitude counterparts, but the advantages of this change for aerobic metabolism have often remained
Kayla M. Garvey, Graham R. Scott
wiley +1 more source
Increased Breeding Frequency Mitigates Inbreeding Depression in Peromyscus in Captivity
Ecology and EvolutionIncreased parental relatedness occurs in small wild populations and in closed colonies in captivity and reduces offspring fitness. A closed colony of Peromyscus maniculatus is maintained as genetically diverse stock at the Peromyscus Genetic Stock Center
Kim‐Tuyen Huynh‐Dam +4 more
doaj +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Tibetan women livingat high altitude exhibit distinct physiological traits that can enhance oxygen transport in chronic hypoxia. Menopausal status influences cardiopulmonary responses to hypoxia in women living at low altitudes.
E. A. Moya +10 more
wiley +1 more source
Immune response genes are up-regulated in deer mice following ANDV infection.
, 2013 Expression of pro- and anti-inflammatory cytokine (A & B) and chemokine (C & D), and T-cell marker mRNAs (E) were assessed by real-time RT-PCR in lungs and/or spleens of deer mice inoculated with ANDV. Mice were euthanized and tissues were harvested 1, 7,
Joseph Prescott (102362) +5 more
core +1 more source
Ecosphere, 2019 Anthropogenic activities are changing landscapes and the context in which predator–prey dynamics evolved, thereby altering key ecological processes and community structure. Yet, the specific mechanisms underlying such changes are rarely understood.
Lindsey E. Sanders, Anna D. Chalfoun
doaj +1 more source
Elliptical β‐barrel deformation underlies gating in VDAC1
Protein Science, Volume 35, Issue 7, July 2026.Abstract Gating by voltage‐dependent anion channels (VDAC) regulates mitochondrial metabolite flux, yet the structural mechanism underlying the open‐to‐closed transition remains unresolved. Here, we combine atomistic molecular dynamics (MD) simulations with double electron–electron resonance (DEER), using hydrostatic pressure as a reversible ...
L. Bergdoll +6 more
wiley +1 more source