Results 281 to 290 of about 2,677,408 (327)

Mitochondrial Calcium Uniporter Drives Chemoresistance in Pancreatic Cancer via Glutathione‐Mediated Stemness Maintenance

Advanced Science, EarlyView.
PDAC has a poor prognosis due to chemoresistance. We revealed that MCU upregulation is associated with chemoresistance and stemness in PDAC. MCU‐mediated Ca2+ influx induced ER stress, activating the PERK‐ATF4/NRF2 axis to enhance PSAT1/SLC711 expression and glutathione synthesis, reducing ROS and maintaining stemness.
Zekun Li, Chenyang Meng, Guangcong Shen, Yueying Shan, Junjin Wang, Diliyaer Abudukeremu, Rui Zhao, Bo Ni, Chao Xu, Xiaofan Guo, Jun Yu, Kaiyuan Wang, Shengyu Yang, YunZhan Li, Yongjie Xie, Tianxing Zhou, Jihui Hao, Xiuchao Wang   +17 more
wiley   +1 more source

Robust uncertainty quantification in popular estimators of the instantaneous reproduction number. [PDF]

Am J Epidemiol
Steyn N, Parag KV.
europepmc   +1 more source

A Study of the Impact of Default Management Practices and Other Factors on Student Loan Default Rates in Public Two-Year Community Colleges.

, 2013
Randell W. Daniels
openalex   +1 more source

USP9X as a Candidate Mediator of Prenatal Aspirin‐Induced Ovarian Reserve Reduction in Offspring Mice

Advanced Science, EarlyView.
This study suggests that prenatal aspirin exposure is associated with reduced ovarian reserve in offspring, associated with HDAC1‐linked epigenetic downregulation of Usp9x as a candidate mechanism. These preclinical findings provide new insights into fetal‐origin ovarian disorders and contribute to the evidence base concerning aspirin's gestational ...
Yating Li, Caiyun Ge, Wai Yen Yim, Hui Feng, Tiancheng Wu, Lu Chen, Qiaohua Xiong, Shumin Pan, Mei Wang, Huijun Chen, Yuanzhen Zhang, Hui Wang   +11 more
wiley   +1 more source

A Neural Signature of the Bias Toward Self-Focus. [PDF]

J Neurosci
Geisler D, Meyer ML.
europepmc   +1 more source

Default Mode Network, Disorganization, and Treatment-Resistant Schizophrenia. [PDF]

Schizophr Bull
Huang H, Qin X, Xu R, Xiong Y, Hao K, Chen C, Wan Q, Liu H, Yuan W, Peng Y, Zhou Y, Wang H, Palaniyappan L.   +12 more
europepmc   +1 more source

Immunisation status and clinical outcomes in children admitted to a Paediatric emergency unit in Ghana: a prospective cohort study. [PDF]

BMC Pediatr
Asafo-Agyei SB, Ameyaw E, Nguah SB, Paintsil V, Ocran AA.   +4 more
europepmc   +1 more source

Challenges in global climate models to represent cloud response to aerosols: insights from volcanic eruptions. [PDF]

Nat Commun
Wang Y, Neubauer D, Chen Y, Jordan G, Malavelle F, Yuan T, Partridge D, Field P, Wang H, Wang M, Michou M, Nabat P, Laakso A, Myhre G, Lohmann U.   +14 more
europepmc   +1 more source

Replication package for "An Exploratory Study on Default Class Openness in Java and Kotlin"

­ Anonymous
openalex   +1 more source