Results 191 to 200 of about 88,203 (308)

H3K27ac Is Essential for Human Naive Pluripotency Modulated by m6A‐Driven EP300 Expression

Advanced Science, EarlyView.
An et al. reveal H3K27ac elevation is essential for establishing and maintaining human naive pluripotency; its inhibition disrupts this state while enhancement promotes it. METTL3‐mediated m6A modification indirectly controls H3K27ac by suppressing EP300 expression. Reduced EP300 lowers H3K27ac, impeding naive pluripotency.
Chenrui An, Ke Zhong, Xiangjin Kang, Yingying Zhang, Yudan Shang, Hao Liu, Yushan Ji, Jinbei Zeng, Jiajin Lin, Long Jin, Zelong Lin, Yang Yu, Xuetao Shi, Yong Fan   +13 more
wiley   +1 more source

Altered glucose metabolism in default mode network and prefrontal circuit in patients with Kallmann syndrome. [PDF]

EJNMMI Res
Zhou C, Wang X, Men M, Yi X, Cao K, Pu W, Hacker M, Li X, Zhao M.   +8 more
europepmc   +1 more source

Integration of Genetic and Imaging Data for Alzheimer's Disease Diagnosis and Interpretation

Advanced Science, EarlyView.
AlzCLIP is a novel contrastive learning framework that integrates single nucleotide polymorphism (SNP) profiles and MRI‐derived imaging features into a unified representation space to improve Alzheimer's disease (AD) diagnosis and interpretation. By achieving superior diagnostic accuracy and revealing key genetic and structural contributors to AD risk,
Yanfei Wang, Qing Wang, Minghao Zhou, Jialu Liang, Lei You, Breton Asken, Xiaobo Zhou, Qianqian Song   +7 more
wiley   +1 more source

A dynamic framework of brain functional patterns shaped by spontaneous thoughts beyond the default mode network. [PDF]

Sci Rep
Cremona S, Gillig A, Mellet E, Joliot M.
europepmc   +1 more source

ggalign: Bridging the Grammar of Graphics and Biological Multilayered Complexity

Advanced Science, EarlyView.
The ggalign package provides a comprehensive framework for composable visualization built on top of ggplot2. Its primary purpose is to enable the construction of complex multi‐plot layouts with consistent observation alignment across plots, particularly for high‐dimensional data contexts such as genomics, transcriptomics, and microbiome studies ...
Yun Peng, Shan Jiang, Yuxuan Song, Peng Luo, Jianfeng Li, Dehua Hu, Jian‐Guo Zhou, Guangchuang Yu, Tao Xu, Shixiang Wang   +9 more
wiley   +1 more source

Default-mode network dysfunction and cognitive impairment in progressive MS [PDF]

, 2013
Sarah A. Kelley
openalex   +1 more source

Default mode network dynamics in covert consciousness

Cortex, 2019
Brian L. Edlow, Zachary D. Threlkeld, Yelena G. Bodien   +2 more
openaire   +3 more sources

Homocysteine Exacerbates Pulmonary Fibrosis via Orchestrating Syntaxin 17 Homocysteinylation of Alveolar Type II Cells

Advanced Science, EarlyView.
The study identifies elevated homocysteine (Hcy) levels in idiopathic pulmonary fibrosis patients' samples, with alveolar type 2 cells as the primary site of Hcy metabolism. Methionine synthase reductase downregulation in these cells exacerbates fibrosis, while folate administration reduces Hcy levels and alleviates fibrosis.
Jiefeng Huang, Ke Fang, Wuyan Lu, Rongrong Wu, Yuanyuan Chen, Linxiao Li, Zihao Hu, Zixin Cai, Yu Jiang, Xinli Fan, Jinyi Deng, Guangpeng Liu, Zhuang Luo, Lei Cui, Shuaijun Li   +14 more
wiley   +1 more source

Cortical morphology changes in default mode network regions as predictors of cognitive decline in relation to amyloid and tau deposits. [PDF]

Brain Commun
Menardi A, Saglam C, La Rocca B, Cecchin D, Venneri A, Cagnin A, Vallesi A.   +6 more
europepmc   +1 more source

Dysfunctional modulation of default mode network activity in attention-deficit/hyperactivity disorder. [PDF]

, 2014
Barış Metin, Ruth M. Krebs, Jan R. Wiersema, Tom Verguts, Roos Gasthuys, J.J. Van der Meere, Eric Achten, Herbert Roeyers, Edmund Sonuga‐Barke   +8 more
openalex   +1 more source