Results 191 to 200 of about 716,083 (340)

Default mode network

, 2018
Anwar Alsulami, Andrew Murphy, Frank Gaillard   +2 more
openaire   +1 more source

Mitochondrial Calcium Uniporter Drives Chemoresistance in Pancreatic Cancer via Glutathione‐Mediated Stemness Maintenance

Advanced Science, EarlyView.
PDAC has a poor prognosis due to chemoresistance. We revealed that MCU upregulation is associated with chemoresistance and stemness in PDAC. MCU‐mediated Ca2+ influx induced ER stress, activating the PERK‐ATF4/NRF2 axis to enhance PSAT1/SLC711 expression and glutathione synthesis, reducing ROS and maintaining stemness.
Zekun Li, Chenyang Meng, Guangcong Shen, Yueying Shan, Junjin Wang, Diliyaer Abudukeremu, Rui Zhao, Bo Ni, Chao Xu, Xiaofan Guo, Jun Yu, Kaiyuan Wang, Shengyu Yang, YunZhan Li, Yongjie Xie, Tianxing Zhou, Jihui Hao, Xiuchao Wang   +17 more
wiley   +1 more source

Neurophysiological signatures of default mode network dysfunction and cognitive decline in Alzheimer's disease [PDF]

Alzheimers Dement
Shafi M.
europepmc   +2 more sources

All roads lead to the default-mode network—global source of DMN abnormalities in major depressive disorder

Neuropsychopharmacology, 2020
A. Scalabrini, B. Vai, S. Poletti, S. Damiani, C. Mucci, C. Colombo, R. Zanardi, F. Benedetti, G. Northoff   +8 more
semanticscholar   +1 more source

USP9X as a Candidate Mediator of Prenatal Aspirin‐Induced Ovarian Reserve Reduction in Offspring Mice

Advanced Science, EarlyView.
This study suggests that prenatal aspirin exposure is associated with reduced ovarian reserve in offspring, associated with HDAC1‐linked epigenetic downregulation of Usp9x as a candidate mechanism. These preclinical findings provide new insights into fetal‐origin ovarian disorders and contribute to the evidence base concerning aspirin's gestational ...
Yating Li, Caiyun Ge, Wai Yen Yim, Hui Feng, Tiancheng Wu, Lu Chen, Qiaohua Xiong, Shumin Pan, Mei Wang, Huijun Chen, Yuanzhen Zhang, Hui Wang   +11 more
wiley   +1 more source

Reduced functional connectivity of default mode network subsystems in depression: Meta-analytic evidence and relationship with trait rumination

NeuroImage: Clinical, 2021
L. Tozzi, Xue Zhang, M. Chesnut, Bailey Holt-Gosselin, C. A. Ramirez, L. Williams   +5 more
semanticscholar   +1 more source

Chromatin Topology Reconfiguration Orchestrates Thermotolerant Male Fertility via GhAL5 in Cotton

Advanced Science, EarlyView.
This study investigates cotton’s high‐temperature (HT) response using multi‑omics. Dynamic 3D genome changes drive expression bias affecting male fertility. The tolerant line shows controlled chromatin dynamics, while the sensitive line exhibits overactivation.
Yanlong Li, Jing Yang, Weiran Wang, Chunyang Zuo, Liuling Pei, Yizan Ma, Rui Zhang, Yaru Fan, Huanhuan Ma, Yawei Li, Ruizhen Liu, Shuangxia Jin, Longfu Zhu, Jie Kong, Xianlong Zhang, Ling Min   +15 more
wiley   +1 more source

Dynamics of the Mammalian Placental Metabolome in Placentogenesis and Embryonic Development

Advanced Science, EarlyView.
This study identifies three metabolic stages (E8.5, E9.5–10.5, E11.5–14.5) and two transition periods (E8.5–9.5, E10.5–11.5) in mouse placental development. NAD(H) emerges as a key dynamic metabolite that enhances embryonic growth through accelerated segmentation and increased proliferation of mouse embryonic stem cell (mESC)‐induced presomitic ...
Gang Chen, Zichen Liu, Mengyi Wei, Qian Li, Liang Wu, Kunyuan Yu, Yanhong Xu, Dainan Yu, Wenwu Ma, Hongmei Wang, Ng Shyh‐Chang, Jinglei Zhai   +11 more
wiley   +1 more source

Default Mode Network, Disorganization, and Treatment-Resistant Schizophrenia. [PDF]

Schizophr Bull
Huang H, Qin X, Xu R, Xiong Y, Hao K, Chen C, Wan Q, Liu H, Yuan W, Peng Y, Zhou Y, Wang H, Palaniyappan L.   +12 more
europepmc   +1 more source

Mapping the subcortical connectivity of the human default mode network

NeuroImage, 2021
Jian Li, William H. Curley, B. Guérin, D. Dougherty, Adrian V. Dalca, B. Fischl, A. Horn, B. Edlow   +7 more
semanticscholar   +1 more source