Results 301 to 310 of about 320,501 (351)

Rethinking the AI Paradigm for Solubility Prediction of Drug‑Like Compounds with Dual‐Perspective Modeling and Experimental Validation

Advanced Science, EarlyView.
Aqueous solubility governs drug delivery and bioavailability, yet its prediction remains challenging. Utilizing the largest curated dataset of drug‐like molecules, prediction models are constructed through dual‐perspective benchmarking. Stacking methods outperform advanced deep learning due to data constraints. These validated models enabled systematic
Qilin Zhu, Yuxin Qiu, Guzhong Chen, Wenyao Chen, Xiang Zhang, Zhiwen Qi, Xuezhi Duan, De Chen, Zhen Song   +8 more
wiley   +1 more source

The architecture of the human default mode network explored through cytoarchitecture, wiring and signal flow. [PDF]

Nat Neurosci
Paquola C, Garber M, Frässle S, Royer J, Zhou Y, Tavakol S, Rodriguez-Cruces R, Cabalo DG, Valk S, Eickhoff SB, Margulies DS, Evans A, Amunts K, Jefferies E, Smallwood J, Bernhardt BC.   +15 more
europepmc   +1 more source

Mechanistic Modeling of Continuous Lyophilization for Biopharmaceutical Manufacturing

Advanced Science, EarlyView.
This article presents the first mechanistic model for continuous lyophilization (aka freeze drying). The model accurately describes the key phenomena and critical process parameters in continuous lyophilization, which can be used for process design, optimization, and control. Results from this work can drive the transition of (bio)pharmaceutical freeze
Prakitr Srisuma, Gang Chen, Richard D. Braatz   +2 more
wiley   +1 more source

Increased individual variability in functional connectivity of the default mode network and its genetic correlates in major depressive disorder. [PDF]

Sci Rep
Yao C, Wang P, Xiao Y, Zheng Y, Pu J, Miao Y, Wang J, Xue SW.   +7 more
europepmc   +1 more source

Immunoregulatory Roles of Tumor‐Originated Pericytes Identified by Single‐Cell Analysis in Glioblastoma

Advanced Science, EarlyView.
The origin and functional heterogeneity of pericytes in glioblastoma (GBM) remain unclear. This study identifies tumor‐originated pericytes (T‐PCs) and normal‐originated pericytes as two distinctive populations in human GBM using single‐cell RNA‐sequencing.
Cuiying Chu, Fangzhen Li, Zhiwen Zhang, Qiuhong Zhu, Hong Yan, Mengdan Cheng, Huipeng Wang, Lei Cheng, Zhe Zhang, Xingjiang Yu, Jianghong Man, Wei Wang, Dongxue Li, Xiu‐wu Bian, Hai‐bo Wu, Aili Zhang, Wenchao Zhou   +16 more
wiley   +1 more source

Author Correction: The architecture of the human default mode network explored through cytoarchitecture, wiring and signal flow. [PDF]

Nat Neurosci
Paquola C, Garber M, Frässle S, Royer J, Zhou Y, Tavakol S, Rodriguez-Cruces R, Cabalo DG, Valk S, Eickhoff SB, Margulies DS, Evans A, Amunts K, Jefferies E, Smallwood J, Bernhardt BC.   +15 more
europepmc   +1 more source

The Default Mode Network and Visual Network Functional Connectivity Changes in Noise-Induced Hearing Loss Patients: A Resting-State fMRI Study. [PDF]

Brain Behav
Lian W, Zhang L, Wang A, Huang R, Zhang H, Bao X, Hang G.   +6 more
europepmc   +1 more source

Default mode network electrophysiological dynamics and causal role in creative thinking. [PDF]

Brain
Bartoli E, Devara E, Dang HQ, Rabinovich R, Mathura RK, Anand A, Pascuzzi BR, Adkinson J, Kenett YN, Bijanki KR, Sheth SA, Shofty B.   +11 more
europepmc   +1 more source

Increased default mode network activation in depression and social anxiety during upward social comparison. [PDF]

Soc Cogn Affect Neurosci
Acuña A, Morales S, Uriarte-Gaspari L, Aguirre N, Brandani A, Huart N, Mattos J, Pérez A, Cuña E, Waiter G, Steele D, Armony JL, García-Fontes M, Cabana Á, Gradin VB.   +14 more
europepmc   +1 more source

Alterations of the default mode network, salience network, and frontoparietal network in non-problematic Internet use and their association with mood regulation: from an internet literacy perspective. [PDF]

Front Neurosci
Shibata M, Tsurumi K, Kobayashi K, Yoshimura S, Spantios M, Oishi N, Murai T, Fujiwara H.   +7 more
europepmc   +1 more source