Results 101 to 110 of about 736,428 (286)
LMO7 Suppresses Tumor‐Associated Macrophage Phagocytosis of Tumor Cells Through Degradation of LRP1
Advanced Science, EarlyView.LMO7 in tumor‐associated macrophages suppresses phagocytosis of tumor cells and limits cytotoxic T lymphocytes infiltration, fostering tumor progression. Mechanistically, LMO7 mediates the ubiquitination and degradation of the phagocytic receptor LRP1, impairing its ability to engulf tumor cells and driving macrophages toward an antitumor phenotype ...
Mengkai Li +12 more
wiley +1 more source
Severe Loss Probabilities in Portfolio Credit Risk Models [PDF]
We derive explicit sharp bounds on the distribution of the number of defaults from a pool of obligors with common probability of default and default correlation.
Babbs, Simon H, Johnson, Andrew E
core +1 more source
Advanced Science, EarlyView.Mature red blood cells (RBCs) can capture extracellular DNA, with short fragments homologous to cfDNA. This uptake is mediated by apoptotic bodies, which induce RBC oxidative stress, deformation, and accelerated in vivo clearance. The rbcDNA abundance correlates with tumor burden and therapeutic response, highlighting its potential as a liquid biopsy ...
Zihang Zeng +20 more
wiley +1 more source
Sovereign risk in a structural approach: Evaluating sovereign ability-to-pay and probability of default [PDF]
We quantify the probability that a sovereign defaults on repayment obligations in foreign currency. Adopting the structural approach as first introduced by Merton, we consider the sovereigns ability-to-pay, characterised by the sum of discounted future ...
Karmann, Alexander, Maltritz, Dominik
core
A Virtual Clinical Trial of Psychedelics to Treat Patients With Disorders of Consciousness
Advanced Science, EarlyView.Disorders of consciousness after severe brain injury are marked by reduced complexity of brain activity and limited treatment options. Using personalized whole‐brain models, this study shows that simulated lysergic acid diethylamide (LSD) and psilocybin shift patient brain dynamics closer to criticality.
Naji L.N. Alnagger +17 more
wiley +1 more source
How much credit should be given to credit spreads? [PDF]
This paper sets out to assess the information that can be derived from spreads between yields on government bonds, considered as having a zero default probability, and yields on risky bonds, i.e. whose default probability is not zero.
Lubochinsky, C.
core
Advanced Science, EarlyView.Cryopreserved lung‐humanized mice overcome the dependency to fresh tissues and permit head‐to‐head profiling of all four human common cold coronaviruses versus SARS‐CoV‐2 infection; the model validates Paxlovid efficacy against HKU1 and, when coupled with human immune‐system engraftment, enables interrogation of lung‐resident human immunity and HKU1 ...
Chunyu Cheng +9 more
wiley +1 more source
The Meaning of Probability of Default for Asset-backed Loans [PDF]
, 2013 The authors examine the concept of probability of default for asset-backed loans. In contrast to unsecured loans it is shown that probability of default can be defined as either a measure of the likelihood of the borrower failing to make required ...
Andersen, Graham, Chisholm, David
core
Advanced Science, EarlyView.Depression, a prevalent neuropsychiatric disorder with unclear pathogenesis, involves dysfunctional adenylyl cyclase 8 (Adcy8) as a key risk factor. Chronic stress selectively reduces Adcy8 expression in the dorsal CA1 (dCA1) neurons. Depletion of Adcy8 in dCA1 excitatory neurons induces depressive‐like behaviors by impairing neuronal excitability and ...
Zi‐Jie Liu +14 more
wiley +1 more source
Credit Risk Assessment Considering Variations in Exposure: Application to Commitment Lines [PDF]
With the worldwide financial market confUsion caused by the subprime mortgage problem and the increase in credit line contracts with relaxed covenants, there are cases where financial institutions are facing demands to provide additional credit to ...
Shigeaki Fujiwara
core +3 more sources