Results 181 to 190 of about 5,859,176 (265)

Similarity‐Enhanced Representation Learning of Non‐Canonical Amino Acids for Therapeutic Peptide Modeling

Advanced Science, EarlyView.
Non‐canonical amino acids (ncAAs) enhance peptide therapeutics but remain difficult to model computationally. SinCAA, a similarity‐enhanced pretraining framework, jointly optimizes contrastive learning guided by a novel conformational similarity metric with masked node reconstruction, capturing both functional relationships and chemical identity of ...
Chencheng Xu, Lesong Wei, Jianmin Wang, Yuanpeng Xiong, Ruochi Zhang, Yu Wang, Chao Zha, Qiangcheng Zeng, Xin Gao   +8 more
wiley   +1 more source

Association Between Total Cholesterol and In-Hospital Mortality Among First-Episode Acute Coronary Syndrome Patients: Multilevel Analysis from NCVD-ACS Registry. [PDF]

Healthcare (Basel)
Tg Abu Bakar Sidik TMI, Shah SA, Kasim S, Selvaraj G, Liu KT, Safian N, Wan Ahmad WA.   +6 more
europepmc   +1 more source

Molecular Glue Degraders Enhance CAPRIN1‐Dependent Lysosomal Degradation of APP and Reduce Amyloid β in Alzheimer's Disease

Advanced Science, EarlyView.
A new class of lysosome‐directed molecular glue degraders selectively enhance CAPRIN1–APP interactions, driving APP degradation and reducing amyloid‐β production in human neurons and Alzheimer's disease mouse models. This CAPRIN1‐dependent targeted protein degradation strategy reveals a previously unrecognized therapeutic approach for disrupting the ...
Sunghan Jung, Xu Wang, Bin Liu, Raktim Roy, Nancy Jaiswal, Ratan K. Rai, Yuichiro Takagi, Cen Gao, Lifan Zeng, Ho‐Yin Lo, Reagan K. Wohlford, Ryan K. Higgins, Bruce T. Lamb, Anantha Shekhar, Anita C. Bellail, Chunhai Hao   +15 more
wiley   +1 more source

Navigating uncertainty matters: Evaluating large language models for drug-drug interaction identification. [PDF]

J Manag Care Spec Pharm
Tilley A, Murray B, Henry K, Zhao X, Gao Y, Blotske K, Sikora A.   +6 more
europepmc   +1 more source

Engineered Transformer Base Editor with Enhanced Editing Efficiency

Advanced Science, EarlyView.
A highly efficient transformer base editor system achieves robust genomic editing in a humanized mouse model. This work establishes a versatile and translatable platform, opening new avenues for precision gene therapy. ABSTRACT Canonical cytosine base editors (CBEs) achieve precise C‐to‐T conversions without inducing DNA double‐strand breaks (DSBs ...
Bowen Chen, Letong Liang, Rui Xu, Tianyi Wang, Hongyan Chen, Daru Lu   +5 more
wiley   +1 more source

Incidence and predictors of treatment default among children aged 6-59 months with severe acute malnutrition in stabilisation centres in western Ethiopia: a prospective follow-up study. [PDF]

BMJ Public Health
Geleta DB, Solbana LK, Chuko LT, Biri IJ, Teina GE, Tarefa YA.   +5 more
europepmc   +1 more source

Static Drainage H2/O2 PEM Fuel Cells Enabled by Water Transport Plates: Pore‐Scale Design and Transport Mechanisms

Advanced Science, EarlyView.
The WTP is a key component of static drainage PEMFCs, enabling cathode water removal and gas sealing through capillary forces. This work investigates the mechanisms governing WTP drainage and sealing performance and develops predictive approaches for WTP design optimization.
Mengdi Guo, Diankai Qiu, Dong Zhu, Linfa Peng   +3 more
wiley   +1 more source

Modification of the existing maximum residue levels for propyzamide in oilseeds and honey. [PDF]

EFSA J
European Food Safety Authority (EFSA), Leite SB, Bellisai G, Bernasconi G, Binaglia M, Castellan I, Castoldi AF, Chiusolo A, Colas M, Crivellente F, Del Aguila M, Ferreira L, Istace F, Lanzoni A, Leuschner R, Louisse J, Mangas I, Mazzega S, Mioč A, Panzarea M, Parra Morte JM, Rizzuto S, Szot M, Tiramani M, Verani A.   +24 more
europepmc   +1 more source

The GPX3‐VCAM1 Axis Gates Pro‐Fibrotic Tubule Cell Fate in Hyperuricemic Nephropathy

Advanced Science, EarlyView.
Hyperuricemia induces NLRP3 inflammasome signaling activation and downregulation of GPX3 in proximal tubular epithelial cells, leading to oxidative stress–driven VCAM1 upregulation, emergence of pro‐fibrotic proximal tubule cells, macrophage recruitment, and renal fibrosis.
Yunfei Qi, Qiang Zhao, Yue Lve, Yaming Yuan, Tingting Zhou, Yue Yuan, Dexi Wu, Yifan Tang, Yan Liu, Zhigang Li, Chunping Jiang, Qiurong Ding   +11 more
wiley   +1 more source

Quality, readability, and clinical-risk signals of default public-interface LLM responses to vascular and perioperative patient questions: a cross-sectional snapshot. [PDF]

Front Public Health
Zhong W, Zhang Y, Huang Y, Yang J, Zheng G, Li Q, Li G, Liu Q.   +7 more
europepmc   +1 more source