Results 101 to 110 of about 91,262 (247)

Longitudinal evaluation of routine data from a malaria outreach training and supportive supervision program in Tanzania–January 2019-November 2022

Discover Public Health
Outreach training and supportive supervision (OTSS) are used to improve malaria case management in many countries in sub-Saharan Africa. Data on coverage and effectiveness of these programs are limited, and this report describes longitudinal coverage and
Erika Wallender, Stella Makwaruzi, Jesus Arias, Francis Levira, Joseph Joseph, Onesmo Mwegoha, Naomi Serbantez, Chonge Kitojo, Erik Reaves, Sarah-Blythe Ballard   +9 more
doaj   +1 more source

Prospective predictors of suicidality: Defeat and entrapment lead to changes in suicidal ideation over time

, 2011
Theoretical perspectives into suicidality have suggested that heightened perceptions of defeat and entrapment lead to suicidality. However, all previous empirical work has been cross-sectional.
Judith Johnson, Gooding, Patricia A., Johnson, Judith; id_orcid, Gooding, Patricia A.; id_orcid, Nicholas Tarrier, Wood, Alex M, Patricia A. Gooding, Taylor, Peter J, Wood, Alex M., Taylor, Peter James, Tarrier, Nicholas, Peter James Taylor, Johnson, Judith, Taylor, Peter J; id_orcid, Gooding, Patricia A, Alex M. Wood   +15 more
core   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Rational Defeat Beyond Belief

Epistemologists typically discuss defeat as applying to beliefs and other cognitive states. But many other kinds of mental states can also be defeated, including emotions.
Schechter, Joshua
core   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

The Defeat of Barisan Nasional Missed Signs or Late Surge?

The results of Malaysia's 14th General Elections of May 2018 were unexpected and transformative. Against conventional wisdom, the newly reconfigured opposition grouping Pakatan Harapan (PH) decisively defeated the incumbent Barisan Nasional (BN), ending ...
Hutchinson, Hutchinson., Lee, Hwok Aun.
core  

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Distinguishing neural ensembles in the infralimbic cortex that regulate stress vulnerability and coping behavior

Neurobiology of Stress
Neural ensembles in the medial prefrontal cortex regulate several types of responses to stress. We used a Syrian hamster model to investigate the role of infralimbic (IL) neurons in coping with social defeat stress and vulnerability to subsequent anxiety-
Jenna L. Laymon, Conner J. Whitten, Anna F. Radford, Alonnah R. Brewer, Yash S. Deo, Mackenzie K. Hooker, Akhil A. Geddati, Matthew A. Cooper   +7 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

The Role of Defeat and Entrapment in Depression, Anxiety, and Suicide

, 2011
Defeat and entrapment are psychological constructs that have played a central role in evolutionary accounts of depression. These concepts have since been implicated in theoretical accounts of anxiety disorders and suicidality. The current article reports
Gooding, Patricia; id_orcid, Taylor, Peter J., Wood, Alexander Mathew, Gooding, Patricia A., Patricia Gooding, Taylor, Peter; id_orcid, Nicholas Tarrier, Wood, Alex M, Taylor, Peter J, Gooding, Patricia, Wood, Alex M., Taylor, Peter James, Tarrier, Nicholas, Peter James Taylor, Gooding, Patricia A, Alex M. Wood   +15 more
core   +1 more source