Results 131 to 140 of about 694,171 (324)
Scientific ReportsSocial defeat stress is associated with endoplasmic reticulum (ER) stress, inflammation and apoptosis. ER stress is thought to contribute to many lifestyle diseases such as liver injury, cardiovascular dysfunction and depression.
XiaoLei Gao +4 more
doaj +1 more source
The Masculine Sea and the Impossibility of Awakening in Chopin's the Awakening [PDF]
, 2012 Kate Chopin has a firm place in American women's writing. A persistent theme in her works is said to be women's emotional liberation. The Awakening (1899) as a feminist novel is no exception.
P, A. (Abbasi)
core
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
“It is not a small thing to defeat a king”. The Servant/Messenger’s Tale in Euripides’ Electra
, 2016 Guido Avezzù
openalex +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
How to Defeat W\"{u}thrich’s Abysmal Embarrassment Argument against Space-Time Structuralism [PDF]
, 2011 In his 2009 PSA Recent Ph.D. Award winning contribution to the bi-annual PSA Conference at Pittsburgh in 2008, C. Wu ̈thrich mounted an argument against struc- turalism about space-time in the context of the General Theory of Relativity (GTR), to the ...
Muller, F.A.
core
Defeating Jamming With the Power of Silence: A Game-Theoretic Analysis [PDF]
, 2014 Salvatore D’Oro +5 more
openalex +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
INDIA'S HEAT WAVE MAY BE DEFEATED BY SUSTAINABLEARCHITECTURE
, 2022 Itika Dadhich +4 more
openalex +1 more source