Caregiver Perspectives on the Burden of Disease and Treatment in Uncontrolled Gout
Objective Uncontrolled gout (UG) refers to persistently elevated serum urate (SU) levels >6 mg/dL and ongoing gout symptoms despite use of urate‐lowering therapy (ULT). The objective of this study was to evaluate the burden associated with informal caregiving for individuals with UG.
Angelo Gaffo +6 more
wiley +1 more source
Cumulative mild stress during early life alters prefrontal astrocytic proteins and elevates peripheral S100B in young adult mice. [PDF]
Kim J, Ko G, Kim JH, Chang KA.
europepmc +1 more source
Objective For cartilage morphology to serve as a scalable endpoint in clinical trials, analyses should be performed automatically without human interaction. To clinically validate artificial intelligence (AI)‐based analysis, we studied cartilage loss from MRI prior to knee replacement.
Felix Eckstein +3 more
wiley +1 more source
Phenotype-Specific Transcriptomic Responses to Glucocorticoid Signaling in the Prefrontal Cortex and Dorsal Raphe Nucleus Following Chronic Social Stress. [PDF]
Ritter P +3 more
europepmc +1 more source
Facial Cosmetic Therapy Use Among Patients With Systemic Sclerosis: An Australian Cohort Study
Objective Systemic sclerosis (SSc) is associated with numerous facial manifestations for which patients may engage in cosmetic therapies. It is unclear how patients with SSc use these therapies. This study sought to characterize patient engagement and experiences with cosmetic therapies for SSc‐related and non‐SSc–related facial changes.
Zachary Warren +11 more
wiley +1 more source
Social hierarchy shapes behavioral and transcriptional responses to chronic stress and ketamine in male mice. [PDF]
Gasperoni S +13 more
europepmc +1 more source
A Q‐Learning Algorithm to Solve the Two‐Player Zero‐Sum Game Problem for Nonlinear Systems
A Q‐learning algorithm to solve the two‐player zero‐sum game problem for nonlinear systems. ABSTRACT This paper deals with the two‐player zero‐sum game problem, which is a bounded L2$$ {L}_2 $$‐gain robust control problem. Finding an analytical solution to the complex Hamilton‐Jacobi‐Issacs (HJI) equation is a challenging task.
Afreen Islam +2 more
wiley +1 more source
Female chronic social defeat stress (<i>fem</i>CSDS) maps synaptic, bioenergetic and metabolic proteome remodeling in the nucleus accumbens (NAc). [PDF]
Patel S +6 more
europepmc +1 more source

