Results 71 to 80 of about 3,022,656 (326)

Novel variants in TNRC6B cause global developmental delay with speech and behavioral abnormalities, short stature, low body weight, café‐au‐lait spots, and metabolic abnormality

Molecular Genetics & Genomic Medicine
Background TNRC6B deficiency syndrome, also known as global developmental delay with speech and behavioral abnormalities (MIM 619243), is a rare autosomal dominant genetic disease mainly characterized by facial dysmorphism, developmental delay ...
Qi Yang, Shan Ou, Xunzhao Zhou, Sheng Yi, Li Lin, Shang Yi, Shujie Zhang, Zailong Qin, Jingsi Luo   +8 more
doaj   +1 more source

Mesoscopic Superconducting Disc with Short-Range Columnar Defects

, 1999
Short-range columnar defects essentially influence the magnetic properties of a mesoscopic superconducting disc.They help the penetration of vortices into the sample, thereby decrease the sample magnetization and reduce the upper critical field. Even the
A. K. Geim, A. K. Geim, A. K. Geim, C. J. van der Beek, D. A. Brawner, D. Saint Jaims, E. H. Brandt, E. Zeldov, G. M. Braverman, Gregory M. Braverman, I. S. Gradstein, J. J. Palacios, L. Civale, P. Singha Deo, R. Benoist, S. T. Stoddart, Sergey A. Gredeskul, V. A. Schweigert, Yshai Avishai, Yu. N. Ovchinnikov   +19 more
core   +1 more source

Defect formation from defect--anti-defect annihilations

, 2012
We show that when a topological defect with extended world-volume annihilates with an anti-defect, there arise topological defects with dimensions less than those of the original defects by one. Domain wall annihilations create vortices while monopole-string annihilations result in instantons.
openaire   +2 more sources

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Screening potential antileukemia ingredients from sweet potato: integration of metabolomics analysis, network pharmacology, and experimental validation

Frontiers in Nutrition
BackgroundActive dietary flavonoids are a promising resource for novel drug discovery. Sweet potato, a widely cultivated functional crop, is abundant in flavonoids.
Lianling Xu, Lianling Xu, Kaixuan Zeng, Kaixuan Zeng, Zuoyue Duan, Zuoyue Duan, Jing Liu, Yan Zeng, Miao Zhang, You Yang, Qulian Guo, Yanling Jin, Wenjun Liu, Ling Guo   +13 more
doaj   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Electronic transport of bilayer graphene with asymmetry line defects

, 2016
In this paper, we study the quantum properties of a bilayer graphene with (asymmetry) line defects. The localized states are found around the line defects.
Chen, Chan, Kou, Su-Peng, Liang, Ying, Wu, Ya-Jie, Zhao, Xiao-Ming   +4 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Exploring the mechanism of fraxetin against acute myeloid leukemia through cell experiments and network pharmacology

BMC Complementary Medicine and Therapies
Objective Previous studies have shown that fraxetin has antitumor activity in a variety of tumors, but its role in acute myeloid leukemia (AML) remains unclear.
Tingting Fang, Lanqin Liu, Wenjun Liu
doaj   +1 more source

Identification of machining defects by Small Displacement Torsor and form parameterization method [PDF]

, 2010
In the context of product quality, the methods that can be used to estimate machining defects and predict causes of these defects are one of the important factors of a manufacturing process.
Bui, Minh-Hien, Duret, Daniel, Favreliere, Hugues, Samper, Serge, Sergent, Alain, Villeneuve, François   +5 more
core   +2 more sources