Results 211 to 220 of about 502,268 (301)

Equal Employment Opportunity Commission, Plaintiff, and Dorothea Huschka and Eric Madigan, Plaintiff-Intervenors, v. Spherion Corporation, Defendant. [PDF]

, 2006
Yeakel, Judge Lee
core   +1 more source

CGRP Enhances the Regeneration of Bone Defects by Regulating Bone Marrow Mesenchymal Stem Cells Through Promoting ANGPTL4 Secretion by Bone Blood Vessels

Advanced Science, EarlyView.
CGRP interacts with HMEC‐1 by binding to surface receptors, influencing the downstream FAK/AKT/VEGF signaling pathway, and promoting the secretion of ANGPTL4 from vascular endothelial cells into the bone microenvironment. This, in turn, regulates the differentiation of BMSCs into osteoblasts, thus promoting bone formation. ABSTRACT Bone angiogenesis is
Qiong Lu, Qiyue Zheng, Zhaokai Zhou, Yajun Chen, Yun Chen, Wenjie Chen, Jiaojiao Wang, Ren Guo, Ren Wu, Lina Chen   +9 more
wiley   +1 more source

Revisiting Spigelian hernia with emphasis on diagnostic challenges and outcomes of open mesh repair: a case report of two patients. [PDF]

Int J Emerg Med
Ogut E, Yildirim FB, Memis O.
europepmc   +1 more source

PIK3CA Mutations Downregulate PPT1 to Promote Adipogenesis by Suppressing P300 Depalmitoylation and Phase Separation

Advanced Science, EarlyView.
This study demonstrates that somatic PIK3CA mutations suppress PPT1 expression via activation of the PI3K–AKT–c‐JUN axis. This reduction in PPT1 weakens its interaction with P300, thereby increasing palmitoylation at C1176 of P300 and protecting P300 from lysosomal degradation.
Hongrui Chen, Zening Huang, Rui Chang, Wei Gao, Yajing Qiu, Bin Sun, Chen Hua, Xiaoxi Lin   +7 more
wiley   +1 more source

In situ flip osteotomy bone block: an alternative bone graft harvesting site proposal for anterior maxillary bone defects. A case report at 3-year follow-up. [PDF]

Oral Maxillofac Surg
Farronato D, Romano L, Poncia L, Azzi L, Levrini L, Farronato M.   +5 more
europepmc   +1 more source

Mitochondrial Transplantation as a Therapeutic Strategy for Inherited Mitochondrial Diseases

Advanced Science, EarlyView.
Mitochondrial transplantation (MTx) offers a promising therapeutic avenue for mitochondrial diseases. This review comprehensively evaluates MTx, differentiating its feasibility for mtDNA‐ and nDNA‐based disorders. It examines its potential for genetic correction, alongside inherent limitations, technical challenges, and crucial ethical considerations ...
Parmeshar Singh, Amir Tahavvori, Cyrus E. Kuschner, Blanca B. Espin, Jacob Kazmi, Sofhia V. Ramos, Tai Yin, Kei Hayashida, Kanako Ito‐Hagiwara, Yusuke Endo, Keitaro Yoshioka, Jun Hagiwara, Avijot Sohi, Alisha Oropallo, Ghania Haddad, Timmy Li, Lance B. Becker, Junhwan Kim   +17 more
wiley   +1 more source

Relationships among depression, anxiety and suicidal ideation in parents of children with congenital heart defects: A dynamic triad. [PDF]

World J Psychiatry
Chinawa JM, Adiele DK, Chinawa AT, Ossai EN, Onyia JT, Onukwuli VO, Chime PU.   +6 more
europepmc   +1 more source

The perils of prenuptial financial agreements:Effectiveness and professional negligence [PDF]

, 2012
Wade, John
core  

Lactylation Reprogramming in the Bone Infection Microenvironment Identifies PGK1 K361 as a Potential Therapeutic Target for Osteogenic Dysfunction

Advanced Science, EarlyView.
Staphylococcus aureus (S. aureus) infection creates a high‐lactate microenvironment, promoting p300‐mediated lactylation of PGK1 at lysine 361 (K361). Lactylated PGK1 translocates to the mitochondrial outer membrane and interacts with VDAC3. This interaction triggers FtMt downregulation, iron accumulation, and excessive PINK1/Parkin‐mediated mitophagy,
Han‐jun Qin, Si‐ying He, Ting‐hui Xiao, Da‐mao Dai, Xin‐jia Hu, Nan Jiang   +5 more
wiley   +1 more source

Anterior abdominal wall agenesis associated with cardiac exstrophy and macrocephaly in a gold mining area of the Democratic Republic of the Congo: management and prognosis in a resource-limited area. [PDF]

Matern Health Neonatol Perinatol
Birindwa EK, Magene RN, Mudekereza PS, Irenge JM, Iragi CN, Munyumbi CK, Asoka BB, Cikomola FG, Cimusa PMK, Nemery B, Kabesha Amani B T, Akilimali TS, Wabulakombe GM, Mulumeoderhwa GM, Amani DSM.   +14 more
europepmc   +1 more source