Results 171 to 180 of about 747 (253)

Selective modulation of NaV channel gating counteracts aberrant hyperexcitability and rescues motor function and survival in a model of spinal muscular atrophy

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Spinal muscular atrophy (SMA) is a motor neuron disease caused by SMN1 gene loss, leading to reduced survival motor neuron (SMN) protein and progressive motor neuron degeneration. Although SMN‐restoring therapies improve outcomes, residual disease burden and non‐curative efficacy underscore the need for complementary treatments ...
Fernanda C. Cardoso   +3 more
wiley   +1 more source

Mass Mobilising for Climate Action: A Member‐Driven Innovation Process in a Nongovernmental Organisation

open access: yesCreativity and Innovation Management, EarlyView.
ABSTRACT Environmental organisations (EOs) are not‐for‐profit organisations that contribute to responsible innovation (RI) efforts to mitigate the climate crisis as central catalysts in society. While the RI discourse in management research acknowledges that collaboration between a broad variety of actors is necessary to foster climate action, so far ...
Ida Raunkjær   +2 more
wiley   +1 more source

Disrupting the Child Welfare Participation Paradigm: A Contextual, Relational, Embedded and Pragmatic Approach

open access: yesChild &Family Social Work, EarlyView.
ABSTRACT Child and parent participation is fundamental to effective child welfare practice. Legislative imperatives assert the right to participate, but in a child welfare context, participation is complex and risks becoming rhetorical. This paper, based on a conceptual synthesis built from second person action research and a narrative review, explores
Jeri L. Damman   +4 more
wiley   +1 more source

Strategic Implications of Board Interlocks: A Literature Review and Future Research Agenda

open access: yesCorporate Governance: An International Review, EarlyView.
ABSTRACT Research Question/Issue Board interlocks, stemming from directors' concurrent board appointments, have been viewed as a double‐edged sword that can generate both positive and negative effects, hinging on strategic outcomes and a multitude of contextual variables.
Joyce C. Wang
wiley   +1 more source

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