Results 241 to 250 of about 482,432 (344)

CypD Dependent mPTP Opening Is Crucial for Oxidized Mitochondrial DNA Release in Ferroptosis

Advanced Science, EarlyView.
Ferroptosis is driven by mitochondrial permeability transition pore (mPTP) opening, which induces mitochondrial swelling and releases oxidized mitochondrial DNA. The released mtDNA activates cGAS–STING signaling, promotes ferritinophagy, and amplifies ferroptotic cell death. Disruption of mtDNA repair sensitizes tumors to ferroptosis in vivo, revealing
Hong Zhou, Wan Fu, Shizuo Liu, Zili Zhang, Hanyan Luo, Qing Zhong   +5 more
wiley   +1 more source

Medical Malpractice Claims for Sports Cardiology Cases Among Young Athletes. [PDF]

JACC Adv
Weller SL, Barat M, Weller Z, Phan F, Moulson N, Churchill TW, Harmon KG, Drezner JA, Baggish AL, Masri A, Petek BJ.   +10 more
europepmc   +1 more source

Integrated Transcriptomics Reveals Evolutionary Trajectories and Cell Density‐Dependent Mechanisms in Aldosterone‐Producing Adenomas

Advanced Science, EarlyView.
Aldosterone‐producing adenomas (APAs) develop via two distinct paths: directly from adrenal zona glomerulosa (zG) cells, or stepwise from zG cells through aldosterone‐producing micronodules (APMs) before progressing to APAs. Advanced single‐cell and spatial analyses identified distinct cell states linked to oxidative stress and cell–cell interactions ...
Zhuolun Sun, Changying Jing, Martina Tetti, Siyuan Gong, Jia Wei, Yingxian Pang, Martin Reincke, Tracy Ann Williams   +7 more
wiley   +1 more source

Injection‑induced sciatic nerve injuries in Turkey: a public health and patient safety analysis of Supreme Court decisions. [PDF]

BMC Med Ethics
Issı ES, İncebacak F.
europepmc   +1 more source

Casenotes: Constitutional Criminal Procedure — Absent a Showing of Prejudice to the Defendant, Due Process Is Not Violated by Prosecutor's Contact with Counsel for Defense Witness in an Effort to Prevent Perjury. United States v. Teague, 737 F.2d 378 (4th Cir. 1984), cert. denied, 105 S.Ct. 913 (1985)

, 1986
Dennis Patrick McGlone
openalex   +1 more source

Midbrain PAG Astrocytes Modulate Mouse Defensive and Panic‐Like Behaviors

Advanced Science, EarlyView.
Astrocytes in the midbrain periaqueductal gray (PAG) dynamically encode threat intensity and shape defensive action selection in mice. Real‐time Ca2+ imaging reveals robust astrocytic activation during predator odor and CO2 exposure. Aberrant astrocytic Ca2+ overactivation disrupts goal‐directed escape, biases behavior toward freezing, and induces ...
Ellane Barcelon, Kyungchul Noh, Minkyu Hwang, Yoon‐Jung Kim, Unjin Lee, Yeon Joo Ryu, Je‐Kyung Ryu, Sang Beom Jun, Se‐Young Choi, Woo‐Hyun Cho, Sung Joong Lee   +10 more
wiley   +1 more source

The Impact of Expert Witness Knowledge on Perceived Credibility: Implications for Not Guilty by Reason of Insanity (NGRI) Endorsement. [PDF]

Behav Sci (Basel)
Cain CF, Smith OKH.
europepmc   +1 more source

When Cooperation Equals Control: What Criminal Defendants and Their Counsel Need to Know to Seek Discovery from Cooperators Through the Government

George L. Phillips
openalex   +1 more source

Brian Wurzel, Plaintiff v. Whirlpool Corporation, Defendant. [PDF]

, 2010
Carr, Judge James G.
core   +1 more source

Gut Microbiota‐Derived Anandamide Mediates the Therapeutic Effects of Urolithin A on Alcohol‐Induced Cognitive and Social Dysfunction via CB1R‐DRD2‐RAP1 Signaling Axis

Advanced Science, EarlyView.
This study reveals that Urolithin A (UA) counteracts alcohol‐induced cognitive and social dysfunction (AICSD) via a gut microbiome‐dependent mechanism. UA‐enriched Bacteroids sartorii and Parabacteroids distasonis elevate anandamide (AEA), which activates the CB1R‐DRD2‐Rap1 signaling cascade to drive synaptic repair and reduce neuroinflammation ...
Hongbo Zhang, Zibin Li, Yao Xiao, Ji Bian, Caian He, Chao Liu, Lan Gong, Lin Han, Zhigang Liu, Min Wang   +9 more
wiley   +1 more source