Results 171 to 180 of about 11,320 (266)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Uncovering the Latent Components of Physical Performance in Professional Soccer: Evidence from the Turkish First Division. [PDF]

J Funct Morphol Kinesiol
Plakias S, Tsaopoulos D, Tsatalas T, Giakas G.   +3 more
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Defend the Public Defenders

, 2021
openaire   +1 more source

Pre-Season Total Energy Expenditure and Dietary Intake of Professional Male Soccer Players: A Doubly Labelled Water Study. [PDF]

Eur J Sport Sci
Jenkinson A, Jones B, Chesson L, Wilson L, Price R, Hambly C, Speakman JR, Costello N.   +7 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

SA3C-ID: a novel network intrusion detection model using feature selection and adversarial training. [PDF]

PeerJ Comput Sci
Huang W, Tian H, Wang L, Wang S, Wang K, Li S.   +5 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Defending human rights defenders

Socialist Lawyer, 2012
openaire   +1 more source

Defender, Passive, and Pro-Bully: Exploring Bystanders' Intentions toward Cyberbullying. [PDF]

Psychosoc Interv
Quintana-Orts C, Alcántara-Lázaro A, Mora-Merchán JA, Del Rey R.   +3 more
europepmc   +1 more source