Results 201 to 210 of about 315,691 (307)

ESCRT‐Mimetic Nanodegrader Targets STING for Anti‐Inflammatory Therapy

Advanced Science, EarlyView.
A nanoplatform‐enabled targeted protein degradation strategy is presented to regulate aberrant STING signaling. STING‐ATTEC induces selective autophagic degradation of STING via formation of a STING–ATTEC–LC3 ternary complex, while the cationic FA‐LNP+ system enhances LC3 generation and targeted delivery. Together, this synergistic approach efficiently
Fuyuan Zhou, Qiming Zhai, Zhihao Yao, Qing Li, Yan Yang, Si Wang, Chao Huang, Liangjing Xin, Tao Chen, Jinlin Song   +9 more
wiley   +1 more source

Data Poisoning Vulnerabilities Across Health Care Artificial Intelligence Architectures: Analytical Security Framework and Defense Strategies. [PDF]

J Med Internet Res
Abtahi F, Seoane F, Pau I, Vega-Barbas M.   +3 more
europepmc   +1 more source

Effective Assistance of Counsel: A Constitutional Right in Transition [PDF]

, 2011

core   +1 more source

Cross‐Modal Denoising and Integration of Spatial Multi‐Omics Data with CANDIES

Advanced Science, EarlyView.
In this paper, we introduce CANDIES, which leverages a conditional diffusion model and contrastive learning to effectively denoise and integrate spatial multi‐omics data. We conduct extensive evaluations on diverse synthetic and real datasets, CANDIES shows superior performance on various downstream tasks, including denoising, spatial domain ...
Ye Liu, Wanpeng Zou, Yuekai Li, Jiayi Wang, Mingxuan Cai, Hongmin Cai   +5 more
wiley   +1 more source

Defense Counsel’s Opening Statements

, 2016
openaire   +1 more source

Post-traumatic stress disorder (PTSD) in Zoulfa Katouh's As Long as the Lemon Trees Grow. [PDF]

Philos Ethics Humanit Med
El Gebali M.
europepmc   +1 more source

Species Dependent Toxicity Comparison Outcome

Advanced Science, EarlyView.
By quantitatively assessing and comparing toxicity responses across different animal species and material compositions, our data reveal that toxicity rankings among different materials may be reversed across species. ABSTRACT Toxicity comparison plays a crucial role in material selection across diverse application fields.
Lian Xiao, Zhan Yu, Sihang Liu, Yuheng Liu, Chong Deng, Yugang Zhao, Yi Huang, Zhi‐Gang Zheng   +7 more
wiley   +1 more source

Certificates of confidentiality: privileging research data. [PDF]

J Law Biosci
Wolf LE, Ram N, Contreras J, Beskow LM.
europepmc   +1 more source

The Public Defender Defendant: A Model Statutory Approach to Public Defender Malpractice Liability [PDF]

, 2011
Richards, David J.
core   +2 more sources