Results 91 to 100 of about 186,690 (314)

Cis‐ and Trans‐Regulatory Factors Independently Shape Phenotypic Heterogeneity of Retinitis Pigmentosa

open access: yesAdvanced Science, EarlyView.
A zebrafish model carrying an identical human RHO S334X allele reveals two independent genetic layers shaping retinitis pigmentosa (RP) severity: a protective 3‐bp cis‐regulatory insertion that attenuates transgene expression, and a dominant trans‐acting modifier that restores a severe phenotype.
Cong Cui   +9 more
wiley   +1 more source

Following the Money: How the 50 States Rate in Providing Online Access to Government Spending Data [PDF]

open access: yes, 2010
Grades states' efforts to provide public spending data through Web portals; lists the benefits of "transparency 2.0," including cost-efficient and targeted spending; and outlines best practices for comprehensive, one-stop, one-click searchable ...
Kari Wohlschlegel, Phineas Baxandall
core  

Plant Genetic Engineering: Technological Pathways, Application Scenarios, and Future Directions

open access: yesAdvanced Science, EarlyView.
This review maps the fast‐evolving landscape of plant genetic engineering, linking enabling platforms with trait‐focused applications in architecture optimization, stress resilience, yield improvement, and quality enhancement. It highlights how genome editing, transgenic strategies, and emerging multi‐gene approaches reshape breeding pipelines, while ...
Peilin Wang   +4 more
wiley   +1 more source

Military Budget and Economic Growth: Case of Middle East, North Africa and South Asia Countries

open access: yesTrikonomika, 2017
Conflict became one of the biggest problems in the Middle East region. This situation will deteriorated the country and will impact on economic perfomance, so defense budget is important to resolve these problems.
Ratni Heliati, Intan Putri Wandiva
doaj   +1 more source

How Much Does the Federal Government Spend to Promote Economic Mobility and for Whom? [PDF]

open access: yes, 2008
Tracks and projects federal expenditures and tax subsidies aimed at enhancing economic mobility, such as employer-related work subsidies, homeownership, savings and investment incentives, and education and training, and who benefits from ...
Adam Carasso   +2 more
core  

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

open access: yesAdvanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong   +24 more
wiley   +1 more source

Functional Inactivation of Mast Cells Enhances Subcutaneous Adipose Tissue Browning in Mice

open access: yesCell Reports, 2019
Summary: Adipose tissue browning and systemic energy expenditure provide a defense mechanism against obesity and associated metabolic diseases. In high-cholesterol Western diet-fed mice, mast cell (MC) inactivation ameliorates obesity and insulin ...
Xian Zhang   +10 more
doaj   +1 more source

The Size and Composition of Government Expenditure [PDF]

open access: yes
This paper tests several leading hypotheses on determinants of government expenditure. The purpose is to avoid omitted variables bias by testing the prominent theories in a comprehensive specification, to identify persistent puzzles for the current set ...
Cameron A. Shelton
core  

Microglia‐Targeted Biomimetic Tetrahedral Framework Nucleic Acid Nanovesicles for Synergistic Treatment of Sepsis‐Associated Encephalopathy

open access: yesAdvanced Science, EarlyView.
Sepsis‐associated encephalopathy (SAE) lacks effective therapies. We developed ME@FDsi, a biomimetic nanodrug using a tetrahedral framework nucleic acid to deliver disulfiram and siTNFα. It crosses the blood‐brain barrier, targets M1 microglia, inhibits pyroptosis and inflammation, and scavenges ROS.
Huimin Shi   +15 more
wiley   +1 more source

COMPULSORY VOTING AND GOVERNMENT SPENDING [PDF]

open access: yes
In a recent issue of Economics and Politics Crain and Leonard (1993) described the effects of compulsory voting on government spending. The purpose of this paper is twofold. First, problems in Crain and Leonard's approach are identified. Their use of the
Eric Strobl, Francis O'Toole
core  

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