Results 91 to 100 of about 1,120,072 (324)

Remimazolam Ameliorates Autistic‐Like Behaviors via Suppression of Ferroptosis in VTA Dopaminergic Neurons in a Mouse Model of ASD

open access: yesAdvanced Science, EarlyView.
The ultra‐short‐acting sedative remimazolam has a sustained therapeutic effect on the core symptoms of VPA‐exposed mice. Remimazolam, a GABA agonist, exerts its therapeutic effects by protecting dopamine neurons in the VTA of VPA‐exposed mice. Meanwhile, ferroptosis is the critical mechanism by which remimazolam protects VTA dopaminergic neurons and ...
Yuxin Zhang   +7 more
wiley   +1 more source

Fiscal policy and economic growth: empirical evidence from EU countries [PDF]

open access: yes
This paper studies whether a reallocation of the components of public spending and revenues can enhance economic growth using data on 14 EU countries during 1990-2006. The results provide support for endogenous growth models.
Benos, Nikos
core   +1 more source

Secrecy vs. Disclosure of the Intelligence Community Budget: An Enduring Debate [PDF]

open access: yes, 2018
Little known U.S. congressional documents, dating from the 1970s, debate public disclosure of Intelligence Community (IC) budget. The documents offer a rich repository of the arguments on both sides of the debate and shine a light on the thoughtful ...
Miles, Anne Daugherty
core   +1 more source

Immune Predictors of Radiotherapy Outcomes in Cervical Cancer

open access: yesAdvanced Science, EarlyView.
This study reveals dynamic immune remodeling in cervical cancer following radiotherapy. Single‐cell analysis identifies the C3/C3AR1 axis as a central mediator of epithelial–myeloid crosstalk, whose inhibition reduces treatment efficacy in mice. Guided by these insights, the eight‐feature machine‐learning model: Cervical Cancer Radiotherapy Immune ...
Linghao Wang   +8 more
wiley   +1 more source

Changing relationships between armaments production and exports and state defense expenditures

open access: yesВестник университета
The present study is relevant, because in different countries of the world in recent years there have been ambiguous dynamics among armaments and military equipment production and exports and changes in state defense expenditures.
D. A. Repnikov
doaj   +1 more source

Flipping the Switch: MeCP2‐Mediated Lactylation Rewires Microglial Metabolism and Inflammation via the HK2/mTOR Axis in Poststroke Neuroinflammation

open access: yesAdvanced Science, EarlyView.
Stroke‐induced lactate accumulation promotes p300‐mediated lactylation of methyl‐CpG binding protein 2 (MeCP2) at lysine 210, which reprograms microglial metabolism toward glycolysis and activates the hexokinase 2 (HK2)/mTOR axis. This cascade promotes proinflammatory responses and impairs neurofunctional outcomes.
Zengyu Zhang   +12 more
wiley   +1 more source

Defense Spending and economic growth in Turkey: an empirical application of new macroeconomic theory [PDF]

open access: yes
This study prsents new empirical evidence on the relationship between the level of of economic growth and defense expenditures in the case of Turkey for the period of 1950-2002.
Ferda Halicioglu
core  

Resolving Malpractice Disputes: Imaging the Jury’s Shadow [PDF]

open access: yes, 1991
The ability of juries to resolve malpractice suits was studied. Results showed that most of the time, jury outcomes represent a fair resolution of the claim, but the risk that the result will not be fair is real and ...
Bergman, Kristoffer, Ekström, Jonatan
core   +1 more source

MicroRNA‐375‐3p Targets Fatty Acid Synthase and Relish to Regulate Energy Allocation During Pupal Metamorphosis and Starvation

open access: yesAdvanced Science, EarlyView.
During pupal metamorphosis and starvation, elevated 20‐hydroxyecdysone (20E) and suppressed insulin trigger Forkhead box O (FOXO) nuclear translocation, enhancing miR‐375‐3p expression. This downregulates fatty acid synthase (FASN) and Relish, promoting lipid breakdown for energy while prioritizing antioxidant responses over immune functions to support
Peng Chen   +10 more
wiley   +1 more source

The prediction of Iran's defensive expenditures up to 2025 horizon using genetic algorithms and PSO [PDF]

open access: yesآینده‌پژوهی دفاعی, 2017
The defense sector is one of the key sectors of Iran that has devoted an important part of the total public spending. Any effort for forecasting the future defense expenditure trend is of special importance for policy-makers of defense sector.
Abolghasem Gholkhandan   +1 more
doaj  

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