Results 91 to 100 of about 1,092,582 (286)

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Psychodynamic aspects of communication skills training: a pilot study [PDF]

, 2018
Goals of work:: Communication between patients and oncology clinicians is a key element of cancer care. Emotionally charged consultations may trigger clinicians' defense mechanisms, protecting them from painful emotions.
Bernard, Mathieu, de Roten, Yves, Despland, Jean-Nicolas, Drapeau, Martin, Favre, Nathalie, Stiefel, Friedrich   +5 more
core  

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

FRNet: A Feature-Rich CNN Architecture to Defend Against Adversarial Attacks

IEEE Access
Adversarial attacks that are possible in natural images are also transferable to medical images, paralyzing the diagnostic process and threatening the robustness of underlying Convolutional Neural Network (CNN) based classifiers.
Neha A S, Vivek Chaturvedi, Muhammad Shafique   +2 more
doaj   +1 more source

The mediating role of early maladaptive schemas in the relationship between attachment styles and defense mechanisms with a positive response to stress in flooded married women in Aq Qala

مجله علوم روانشناختی, 2023
Background: Numerous studies have investigated the relationship between attachment styles and defense mechanisms with early maladaptive schemas.
sona khakpoor, afsaneh khajvand khoshli, ramazan hassanzadeh, javanshir asadi   +3 more
doaj  

The Relationship Between Inflammation and Central Nervous System in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Aim Multiple sclerosis is an autoimmune demyelination disease that is seen especially in the young population and has a progressive course, causing motor, sensory, and cognitive deficits. In the literature, the pathogenesis of MS disease and the interconnection between the immune and central nervous system in the disease have not been fully ...
Gamze Ansen, Ali Behram Salar, Abdulkadir Ermis, Erkingul Birday, Lutfu Hanoglu, Bayram Ufuk Sakul   +5 more
wiley   +1 more source

Defense Mechanism Of John Brennan In Paul Haggis’s The Next Three Days Movie (2010): A Psychoanalytic Approach [PDF]

, 2012
This study is aimed to show the defense mechanism that the major character has by using psychoanalytic approach. It is done by establishing two objectives: the first is analyzing the movie based on its structural elements and the seconds is analyzing the
Rayuni, Feni Dhian Cheri
core  

Pulmonary Antioxidant Defense Mechanisms

Experimental Lung Research, 1985
Intrinsic enzymatic and non-enzymatic pulmonary antioxidant defense mechanisms undoubtedly protect the lung against oxidant-mediated environmental stresses and diseases. In addition, new ways of augmenting pulmonary antioxidant defenses are being developed which can be used to bolster disease-overwhelmed intrinsic lung defense mechanisms.
C W, White, J E, Repine
openaire   +2 more sources