Results 131 to 140 of about 9,269,203 (381)

NR4A1 Exerts Pro‐Tumor Role in Glioblastoma via Inducing xCT/GPX4‐Regulated Ferroptosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Purpose This study investigates NR4A1's paradoxical roles in glioblastoma (GBM) progression, focusing on its mechanistic link to ferroptosis regulation. We aimed to resolve conflicting reports of NR4A1 as both an oncogene and a tumor suppressor by defining its transcriptional control over xCT/GPX4‐mediated iron homeostasis and its clinical ...
Peng Tao, Shikuan Din, Zhengkang Fu, Qian Sun, Xiwei Zhu, Yuxin Wei, Huan Qu, Xinyi Zhang, Jiaxuan Liu, Chuhua Fu, Qianxue Chen   +10 more
wiley   +1 more source

C-Terminal Domain of Hemocyanin, a Major Antimicrobial Protein from Litopenaeus vannamei: Structural Homology with Immunoglobulins and Molecular Diversity

Frontiers in Immunology, 2017
Invertebrates rely heavily on immune-like molecules with highly diversified variability so as to counteract infections. However, the mechanisms and the relationship between this variability and functionalities are not well understood.
Yue-Ling Zhang, Bo Peng, Hui Li, Fang Yan, Hong-Kai Wu, Xian-Liang Zhao, Xiang-Min Lin, Shao-Ying Min, Yuan-Yuan Gao, San-Ying Wang, Yuan-You Li, Xuan-Xian Peng   +11 more
doaj   +1 more source

Pulmonary Antioxidant Defense Mechanisms

Experimental Lung Research, 1985
Intrinsic enzymatic and non-enzymatic pulmonary antioxidant defense mechanisms undoubtedly protect the lung against oxidant-mediated environmental stresses and diseases. In addition, new ways of augmenting pulmonary antioxidant defenses are being developed which can be used to bolster disease-overwhelmed intrinsic lung defense mechanisms.
C W, White, J E, Repine
openaire   +2 more sources

Plasma Proteomic Signatures for Alzheimer's Disease: Comparable Accuracy to ATN Biomarkers and Cross‐Platform Validation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background There is growing recognition of the potential of plasma proteomics for Alzheimer's Disease (AD) risk assessment and disease characterization. However, differences between proteomics platforms introduce uncertainties regarding cross‐platform applicability.
Manyue Hu, Oliver Robinson, Christina M. Lill, Anna Matton, Raquel Puerta, Pilar Sanz, Merce Boada, Agustín Ruiz, Lefkos Middleton, for the Alzheimer's Disease Neuroimaging Initiative   +9 more
wiley   +1 more source

The Relationship Between Inflammation and Central Nervous System in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Aim Multiple sclerosis is an autoimmune demyelination disease that is seen especially in the young population and has a progressive course, causing motor, sensory, and cognitive deficits. In the literature, the pathogenesis of MS disease and the interconnection between the immune and central nervous system in the disease have not been fully ...
Gamze Ansen, Ali Behram Salar, Abdulkadir Ermis, Erkingul Birday, Lutfu Hanoglu, Bayram Ufuk Sakul   +5 more
wiley   +1 more source

Contribution of transcription factor, SP1, to the promotion of HB‐EGF expression in defense mechanism against the treatment of irinotecan in ovarian clear cell carcinoma [PDF]

, 2014
Kohei Miyata, Fusanori Yotsumoto, Sung Ouk Nam, Takashi Odawara, Sadao Manabe, Toyokazu Ishikawa, Hiroaki Itamochi, Junzo Kigawa, Shuji Takada, Hiroshi Asahara, Masahide Kuroki, Shingo Miyamoto   +11 more
openalex   +1 more source

Frailty Exacerbates Disability in Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background To evaluate frailty in severe progressive multiple sclerosis (PMS) and to investigate the underlying mechanisms. Methods This prospective, cross‐sectional, multicenter study enrolled a late severe PMS group requiring skilled nursing (n = 53) and an age, sex, and disease duration‐matched control PMS group (n = 53).
Taylor R. Wicks, Anna Wolska, Diala Ghazal, Dejan Jakimovski, Bianca Weinstock‐Guttman, Alexander Burnham, Niels Bergsland, Michael G. Dwyer, Alan T. Remaley, Robert Zivadinov, Murali Ramanathan   +10 more
wiley   +1 more source

Immature defense mechanisms mediate the relationship between negative life events and depressive symptoms

Frontiers in Psychiatry
ObjectiveThis study aimed to analyze the patterns of life events (LEs) and defense mechanisms in outpatients with depression and investigate the mediating role of defense mechanisms in the association between LEs and depressive symptoms in a ...
Dandan Ma, Jinya Cao, Jing Wei, Jing Jiang   +3 more
doaj   +1 more source

In silico characterization of a pathogenesis-related protein PR-1 from Theobroma grandiflorum : S01P11 [PDF]

, 2013
The cupuassu (Theobroma grandiflorum [Wild. Ex Sperg.] K. Schum) is a native species of Brazil with a large industrial potential related to the use of the fruit pulp and seeds.
Alves, Rafael Moyses, Marcellino, Lucilia Helena, Micheli, Fabienne, Silva, Edson M.A, Silva, R.J.S   +4 more
core  

Sex Hormones Associate With Amyotrophic Lateral Sclerosis Risk and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Amyotrophic lateral sclerosis (ALS) risk differs by sex and age, implicating sex hormones as potential modifiers. This study examined plasma levels of biologically active sex hormones and their association with ALS odds and survival in cases (females n = 131, males n = 189) and controls (females n = 138, males n = 150) from the University of ...
Stephen A. Goutman, David G. Stouffer, Dae‐Gyu Jang, Jihyun Park, Benjamin J. Murdock, Richard J. Auchus   +5 more
wiley   +1 more source