Results 241 to 250 of about 1,804,115 (312)

A Biomarker‐Driven Ovary–Endometrium Organ‐on‐a‐Chip Mimicking 3D Multicellular Complexity and Menstrual Cyclicity for Predicting Reproductive Toxicity

Advanced Science, EarlyView.
We present a dual‐organ, biomarker‐integrated ovaryendometrium organ‐on‐a‐chip that recapitulates 3D tissue complexity, menstrual cycle dynamics, and hormonal crosstalk. This platform enables real‐time, cell‐typespecific fluorescent readouts of reproductive toxicity using ANGPTL4 and SERPINB2 as early‐response reporters.
Soo‐Rim Kim, Eun‐kyung Min, Choon‐Mi Lee, Chan Hum Park, Byung‐Chul Oh, YunJae Jung, In‐Sun Hong   +6 more
wiley   +1 more source

GATA4‐Driven Transcription of HtrA1 Promotes Cellular Senescence in Ménière's Disease and Age‐Related Audio‐Vestibular Dysfunction

Advanced Science, EarlyView.
This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang, Na Li, Yan Wang, Jing Zhang, Jiahui Liu, Lei Chen, Yongdong Song, Yurong Mu, Yuechen Han, Yafeng Lyu, Xiaofei Li, Hanyue Wang, Jing Wang, Yao Lu, Zhaomin Fan, Daogong Zhang, Haibo Wang   +16 more
wiley   +1 more source

Post-operative septic arthritis after anterior cruciate ligament reconstruction results in higher osteoarthritis severity and deficit of range of motion: A matched control analysis with a minimum 8-year follow-up. [PDF]

J Exp Orthop
Imach S, Ubl ST, Flieser C, Stüber J, Shafizadeh S, Wafaisade A, Naendrup JH, Guenther D, Bouillon B, Pfeiffer TR.   +9 more
europepmc   +1 more source

Rapid Early Motor Improvement After Full Endoscopic Interlaminar Discectomy for L4-L5 Disc Herniation Presenting With Foot Drop: A Case Report. [PDF]

Cureus
Kaya M, Bakac MÖ, Kacira T, Kocer S.
europepmc   +1 more source

Traits Explain Canopy Tree Occurrence Along Regional Environmental Gradients: A Subset Combine to Be Useful. [PDF]

Ecol Evol
Vesk PA, Windecker SM, Gallagher RV, Morris WK, Pollock LJ, Towers IR, Falster DS.   +6 more
europepmc   +1 more source

Seed priming with two types of glassy microparticles in cowpea subjected to water deficit induced by polyethylene glycol 6000. [PDF]

BMC Plant Biol
Barroso VSF, Dias GF, de Alencar RS, Bonou SI, de Oliveira Viana PM, Cavalcante IE, da Silva Soares AC, da Costa Melo EM, Schneider R, de Luna Souto AG, de Mesquita EF, de Oliveira AMF, de Melo AS.   +12 more
europepmc   +1 more source

Shared and Unique Connectivity Signatures of Reading and Language Deficits. [PDF]

J Cogn Neurosci
Daucourt MC, Rosenblatt M, Frijters JC, Bosson-Heenan JM, Gruen JR, Scheinost D.   +5 more
europepmc   +1 more source

Pure global amusia in a professional opera singer. [PDF]

Neurol Sci
Priftis K, Giordano BL.
europepmc   +1 more source