Results 141 to 150 of about 2,330,831 (316)

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

open access: yesFEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara   +3 more
wiley   +1 more source

SUPEROPT: Problem Definition and Literature Review:D1

open access: yes, 2012
This report summarises the output of WP1: Detailed Problem Definition of the SESAR SUPEROPT project. A pair of challenge scenarios is defined and the proposed optimizers described. The set of scenarios are expanded to define the concepts to be studied in
Richards, Arthur G, Turnbull, Oliver D N
core  

Non-standard dictionary definitions: What they cannot tell native speakers of Polish [PDF]

open access: yes, 2006
Recently, a new defining format has been gaining in popularity in abstract noun entries of monolingual English learners’ dictionaries: a single-clause when-definition. The present study attempts to investigate the role of the definition of this format,
Lew, Robert, Dziemianko, Anna
core  

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Definition and description of interjections in the first grammar books of the Romanian language (1667-1914) [PDF]

open access: yesDiversitate si Identitate Culturala in Europa
a diachronic perspective, highlights, on the one hand, a clear evidence of its belonging to the category of inflexible parts of speech. On the other hand, the semantic constant of the interjection with reference to the notion of state of mind is ...
Alina Marieta RUCĂREANU (Maica ALEXANDRA)
doaj  

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Project Leader of WPDTT2 (Definition and design of the Divertor Tokamak Test facility)

open access: yes, 2014
EFDA published “Fusion Electricity – A roadmap to the realisation of fusion energy” 0 in November 2012 that sets out a strategic vision to demonstrate the generation of electrical power by a Demonstration Fusion Power Plant (DEMO) by 2050.
ALBANESE, Raffaele
core  

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

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