Results 41 to 50 of about 2,878,495 (255)

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Effects of Plastic Deformation on the Transport Properties of Rocksalt [PDF]

open access: yes, 2018
It has recently been suggested that plastic deformation of rocksalt in nature can lead to the development of significant permeability to fluids, even under fully ductile deformation conditions.
Sinn, C.J.A.   +5 more
core  

The influence of hydrostatic pressure on the interlaminar fracture toughness of carbon/epoxy composites [PDF]

open access: yes, 2006
The use of composites for deep sea applications requires a thorough understanding of the behaviour of these materials. While several studies have examined the influence of pressure on in-plane properties few data are available for the interlaminar ...
Peleau, M.   +3 more
core   +1 more source

Dynamic Structural Response of a Corrugated Blast Wall Under Hydrogen Blast Loads

open access: yesApplied Sciences
A literature review was conducted to examine blast load characteristics of hydrogen, and the trend of hydrogen blast load and correlations between load characteristics were analyzed and compared with those of hydrocarbons.
Hyunho Lee, Jungkwan Seo
doaj   +1 more source

Effect of Constitutive Equations on Springback Prediction Accuracy in the TRIP1180 Cold Stamping

open access: yesMetals, 2017
This study aimed to evaluate the effect of constitutive equations on springback prediction accuracy in cold stamping with various deformation modes. This study investigated the ability of two yield functions to describe the yield behavior: Hill’48 and ...
Ki-Young Seo   +4 more
doaj   +1 more source

Strain-rate sensitivity of brittle deformation and removal mechanisms of monocrystalline 3C–SiC induced by nano cutting process

open access: yesJournal of Materials Research and Technology, 2023
In this work, the dynamic crack propagation mechanism of 3C–SiC at the micro-scale and the influence mechanism of the strain rate effect are studied, and the deformation mechanism under different strain rate is deeply analyzed.
Binbin Meng, Chen Li
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

Deformation and failure mechanism of shield tunnels in longitudinally heterogeneous ground under strong earthquakes

open access: yesShuiwen dizhi gongcheng dizhi
Nonuniform soil profiles can induce seismic ground-motion amplification and deformation incompatibility, thereby intensifying the seismic response and altering the deformation patterns of shield tunnels. To address this critical issue, this study takes a
Xiaojun TAO   +4 more
doaj   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

open access: yesFEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Rheology of synthetic rocksalt : with emphasis on the influence of deformation history and geometry on the flow behaviour [PDF]

open access: yes, 1993
The present study consists of an experimental investigation into the deformation behaviour of synthetic polycrystalline rocksalt (NaCl) in uniaxial compression and in simple shear.
IVAU: Instituut voor Aardwetenschappen Utrecht   +2 more
core   +1 more source

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