Results 151 to 160 of about 7,813 (185)

Restoring Iron Homeostasis via Smoothened Inhibition: A Novel Strategy Against Hearing Loss

Advanced Science, EarlyView.
 . ABSTRACT Sensorineural hearing loss (SNHL) induced by noise or aminoglycoside antibiotics is a significant public health concern without any FDA‐approved pharmaceutical therapies. Dysregulation of iron homeostasis and its subsequently induced ferroptosis has increasingly been identified as a key mechanism underlying cochlear hair cell (HC) damage ...
Huanyu Mao, Xiang Li, Yaqi Liao, Liman Liu, Xian Gao, Hailiang Lin, Wenli Ni, Huawei Li, Yan Chen, Wenyan Li   +9 more
wiley   +1 more source

Challenges and opportunities in technologies and methods for lncRNA structure determination. [PDF]

Cell Biosci
De Souza Degenhardt MF, Wang YX.
europepmc   +1 more source

Mild Focal Cooling Decouples Dendrites to Reconfigure Cortical Output

Advanced Science, EarlyView.
Mild cooling of the cortical surface selectively modulates apical dendritic excitability, plasticity, and somato‐dendritic coupling, while uncoupling these effects from basal dendrites, and reshapes apical‐driven responses in barrel cortex during whisker touch.
Meisam Habibi Matin, Shulan Xiao, Krishna Jayant   +2 more
wiley   +1 more source

Cavity-enhanced continuous-wave microscopy with potentially unstable cavity length. [PDF]

Sci Rep
Lueghamer O, Nimmrichter S, Conrad-Billroth C, Juffmann T, Prüfer M.   +4 more
europepmc   +1 more source

An Implanted Tooth That Can Feel

Advanced Science, EarlyView.
To endow the implanted tooth with masticatory perception, herein we demonstrate that a 3D‐printed piezoelectric‐core/robust‐sheath implanted tooth can rebuild the sensing feedback, serving as “mechanoreceptors” in converting the mechanical chewing force to electrical signals, and up to brain through surrounding alveolar nerve system.
Yaru Cao, Zhenhua Wu, Jiwei Sun, Ke Song, Jiayi Li, Yujin Li, Wenqi Chen, Hanyu Li, Shue Li, Cheng Yang, Silin Liu, Yunyun Han, Bin Su, Yumei Ding   +13 more
wiley   +1 more source

Thermal-bias PCR: generation of amplicon libraries without degenerate primer interference. [PDF]

PeerJ
Moore SD.
europepmc   +1 more source

A Guide for Spatial Omics Technologies: Innovation, Evaluation, and Application

Advanced Science, EarlyView.
This review presents a strategy‐centric framework for spatial omics technologies, organizing methods by how spatial information is experimentally encoded. It compares key performance trade‐offs across sequencing‐ and imaging‐based approaches, examines computational and practical limitations, and highlights biomedical applications. The analysis provides
Xiaofeng Wu, Weize Xu, Da Lin, Leqiang Sun, Jinxia Dai, Gang Cao   +5 more
wiley   +1 more source

Gene regulatory networks: from correlative models to causal explanations. [PDF]

Nat Rev Genet
Maizels RJ, Briscoe J.
europepmc   +1 more source

An evolutionary medicine and life history perspective on aging and disease: Trade-offs, hyperfunction, and mismatch. [PDF]

Evol Med Public Health
Aronoff JE, Trumble BC.
europepmc   +1 more source

tRNA modifications as regulators of bacterial virulence and stress responses. [PDF]

PLoS Pathog
Teixeira C, Vandenesch F, Moreau K.
europepmc   +1 more source