Results 91 to 100 of about 1,240,454 (293)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
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Effective diffusion tensor computed by homogenization [PDF]
, 2013 The convergence of the long-time apparent diffusion tensor of diffusion magnetic resonance imaging (dMRI) to the effective diffusion tensor obtained by mathematical homogenization theory was considered for two-compartment geometric models containing non ...
Grebenkov, Denis +4 more
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Parameter inference for degenerate diffusion processes
Stochastic Processes and their ApplicationsWe study parametric inference for ergodic diffusion processes with a degenerate diffusion matrix. Existing research focuses on a particular class of hypo-elliptic SDEs, with components split into `rough'/`smooth' and noise from rough components propagating directly onto smooth ones, but some critical model classes arising in applications have yet to be
Yuga Iguchi +2 more
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Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
A degenerate migration-consumption model in domains of arbitrary dimension
Advanced Nonlinear StudiesIn a smoothly bounded convex domain Ω⊂Rn ${\Omega}\subset {\mathbb{R}}^{n}$ with n ≥ 1, a no-flux initial-boundary value problem forut=Δuϕ(v),vt=Δv−uv, $$\begin{cases}_{t}={\Delta}\left(u\phi \left(v\right)\right),\quad \hfill \\ {v}_{t}={\Delta}v-uv ...
Winkler Michael
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Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Solid-state diffusion and NMR [PDF]
, 2005 Diffusion in solids, which requires the presence of crystal defects or disorder, has both microscopic and macroscopic aspects. Nuclear magnetic resonance techniques provide access to microscopic diffusion parameters like atomic jump rates and activation ...
Heitjans, Paul +2 more
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Electronic Journal of Differential Equations, 2018 This article shows Carleman estimate and null controllability of a cascade control system governed by the semilinear degenerate parabolic equations with the general convection terms.
Jianing Xu, Chunpeng Wang, Yuanyuan Nie
doaj
The Degenerate Neumann Problem and Degenerate Diffusions with Venttsel's Boundary Conditions
The Annals of Probability, 1981 A stochastic solution of the Neumann problem is obtained, when the second order elliptic operator $L$ is degenerate at the boundary of the domain. Let $D$ be a domain in $R^n$ with the smooth boundary $\partial D$, and the second order elliptic operator $L$ be defined in $R^n$.
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FEBS Open Bio, EarlyView.Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley +1 more source