Results 21 to 30 of about 75,109 (198)

On the size of p-adic Whittaker functions

, 2018
In this paper we tackle a question raised by N. Templier and A. Saha concerning the size of Whittaker new vectors appearing in infinite dimensional representations of GL(2) over non-archimedean fields.
Assing, Edgar
core   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Complex actions in two-dimensional topology change

, 1997
We investigate topology change in (1+1) dimensions by analyzing the scalar-curvature action $1/2 \int R dV$ at the points of metric-degeneration that (with minor exceptions) any nontrivial Lorentzian cobordism necessarily possesses. In two dimensions any
, , Allendoerfer C A, Anderson A, Ashtekar A, Balasin H, Bombelli L, Bombelli L, Bott R, Carlip S, Chern S S, Clarke C J S, Daughton A, Deser S, Deser S, Dray T, Ellis G, Ellis G F R, Gibbons G W, Gott R, Harris S G, Hawking S W, Hawking S W, Hayward S A, Hayward S A, Horowitz G T, Horowitz G T, Horowitz G T, Israel W, Jee D J, Jorma Louko, Kossowski M, Law P, Linet B, Louko J, Lovelock D, Lovelock D, Manogue C A, Misner C W, Rafael D Sorkin, Reed M, Romano J D, Sakharov A D, Salgado R, Schwartz L, Sorkin R D, Sorkin R D, Sorkin R D, Spivak M, Tod K P, Vickers J A G, Vickers J A G, Wald R M   +52 more
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ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Numerical solution of degenerate stochastic Kawarada equations via a semi-discretized approach

, 2018
The numerical solution of a highly nonlinear two-dimensional degenerate stochastic Kawarada equation is investigated. A semi-discretized approximation in space is comprised on arbitrary nonuniform grids.
Padgett, Joshua L, Sheng, Qin
core   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

New L2-type exponentiality tests [PDF]

, 2019
We introduce new consistent and scale-free goodness-of-fit tests for the exponential distribution based on the Puri-Rubin characterization. For the construction of test statistics we employ weighted L2 distance between V-empirical Laplace transforms of ...
Cuparić, Marija, Milosević, Bojana, Obradović, Marko   +2 more
core  

SmallTalk: a novel small‐sized fusion tag for peptide expression and purification

FEBS Open Bio, EarlyView.
The SmallTalk fusion tag allows for the efficient expression and purification of soluble recombinant proteins or peptides in Escherichia coli. Testing with SmallTalk‐GFP confirmed that the proteins were soluble and folded correctly, while SmallTalk‐Bin1b maintained its antimicrobial activity against various bacterial isolates. This streamlined workflow
Atika Tariq, Nestor G. Casillas‐Vega, Alma Gomez‐Loredo, Xristo Zarate   +3 more
wiley   +1 more source

Enhancement of Quantum Tunneling for Excited States in Ferromagnetic Particles

, 1997
A formula suitable for a quantitative evaluation of the tunneling effect in a ferromagnetic particle is derived with the help of the instanton method.
A. Garg, A. J. Leggett, A. Perelomov, D. A. Garanin, D. D. Awschalom, D. D. Awschalom, D. D. Awschalom, E. Fradkin, E. M. Chudnovsky, F. Zimmerschied, F.-C. Pu, H. J. W. Müller-Kirsten, J. L. van Hemmen, J.-G. Zhou, J.-G. Zhou, J.-Q. Liang, J.-Q. Liang, J.-Q. Liang, J.-Q. Liang, J.-Q. Liang, J.-Q. Liang, J.-Q. Liang, J.-Q. Liang, J.-Q. Liang, Jian-Ge Zhou, L. D. Faddeev, L. Gunther, M. Enz, M. Enz, N. S. Manton, Y.-B. Zhang   +30 more
core   +1 more source