Results 101 to 110 of about 1,770 (170)

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Pathogenesis and Treatment of Non-alcoholic Steatohepatitis and Its Fibrosis: A Systematic Review. [PDF]

Cureus
Ahmed T, Farooq S, Naveed MA, Shahzad A, Rehman W, Haider T, Noor NN.   +6 more
europepmc   +1 more source

Tailored Monolayer Co‐Assembly for Enhanced Efficiency and Stability in Inverted Perovskite Solar Cells

Advanced Science, EarlyView.
This work presents a co‐assembled monolayer, Cys‐S‐2PACz, constructed via sequential deposition. The size‐complementary pairing and competitive anchoring between Cys and S‐2PACz enable dense and highly ordered molecular packing. Meanwhile, the synergistic passivation from the methylthio and thiol groups effectively suppresses interfacial recombination,
Fen Xia, Shuwen Yang, Xiaolin Liu, Jing Zhang, Jun Yin, Jing Li, Zhaohui Wang, Song Tu, Binghui Wu, Nanfeng Zheng   +9 more
wiley   +1 more source

Critical analysis of polycyclic tetramate macrolactam biosynthetic gene cluster phylogeny and functional diversity. [PDF]

Appl Environ Microbiol
Harper CP, Day A, Tsingos M, Ding E, Zeng E, Stumpf SD, Qi Y, Robinson A, Greif J, Blodgett JAV.   +9 more
europepmc   +1 more source

Giant Isotope Effect in Metal–Organic Frameworks Boosts Unprecedented Photo‐ and Radio‐Luminescence Enhancement

Advanced Science, EarlyView.
Deuterated MOFs in this work exhibited unprecedented giant luminescence isotope effect via O─H oscillator suppression, achieving maximal solid‐state materials emission enhancement. This yields significantly improved X‐ray detection sensitivity and imaging resolution, marking the first integration of MOFs with isotopic luminescence and opening new ...
Junhao Lu, Dan Zhou, Xianhuan Hao, Hao Lu, Zhongyuan Zhang, Yuhuan Jia, Sen Mei, Ye Huang, Songbai Tang, Zhiyong Peng, Lanhua Chen, Mengjia Yuan, Lixi Chen, Shuaihua Wang, Meiling Feng, Yanlong Wang, Shuao Wang   +16 more
wiley   +1 more source

From Isolation to Genomics: Characterization of <i>Aspergillus uvarum</i> HT4 as a Novel Producer of Extracellular Tannase. [PDF]

J Fungi (Basel)
Arbildi E, Ovsejevi K, Roldán D, Durán R, Portela M, Garmendia G, Vero S.   +6 more
europepmc   +1 more source

Salt Water Drops Slide Faster: Ionic Modulation of Drop Friction

Advanced Science, EarlyView.
Salt ions markedly accelerate water drops on conductive substrates coated with nanometer‐thin hydrophobic layers. Across diverse electrolytes and surfaces, higher ion concentration consistently lowers kinetic friction by reducing contact angle hysteresis.
Dongho Shin, Rutvik Lathia, Chirag Hinduja, Hyunbae Cheon, Seongmin Park, Hans‐Jürgen Butt, Junwoo Park   +6 more
wiley   +1 more source

Quantitative modelling of biological response dynamics reveals novel patterns in plant volatile signalling

Waterman JM, Moore GJ, Amdahl-Culleton LK, Hoefer S, Erb M.   +4 more
europepmc   +1 more source

Tumor-associated endothelial cells in tumor immune escape and immunotherapy: multifaceted roles and treatment approaches. [PDF]

Biomark Res
Zheng T, Yu X, Yu C, Xu W, Fan Z, Zhou Y, Li C, Wan J, Jin C, Jin X, Zhang W, Yan Z, Luo P, Tang B, Qu X.   +14 more
europepmc   +1 more source

Engineering Immune Cell to Counteract Aging and Aging‐Associated Diseases

Advanced Science, EarlyView.
This review highlights a paradigm shift in which advanced immune cell therapies, initially developed for cancer, are now being harnessed to combat aging. By engineering immune cells to selectively clear senescent cells and remodel pro‐inflammatory tissue microenvironments, these strategies offer a novel and powerful approach to delay age‐related ...
Jianhua Guo, Lanjie Lei, Ying Jin, Lan Su, Shumao Cui, Liyun Shi   +5 more
wiley   +1 more source