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Methylmalonic Acid, an Aging-Associated Metabolite, Accelerates Intervertebral Disc Degeneration by Inducing Disc Vascularization via the CCL7/JAK2-STAT3/VEGF Signaling Axis. [PDF]
Jin Y +6 more
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Age-related macular degeneration
Age-related macular degeneration (AMD) is a leading cause of blindness. The main risk factor is advancing age, with the severity of vision loss ranging from mild to severe. There is a 25% risk of early AMD and 8% risk of late AMD in patients over the age
Monika Fleckenstein +2 more
exaly +2 more sources
HO-1-mediated ferroptosis as a target for protection against retinal pigment epithelium degeneration
Oxidative stress-mediated retinal pigment epithelium (RPE) degeneration plays a vital role in retinal degeneration with irreversible visual impairment, most notably in age-related macular degeneration (AMD), but a key pathogenic factor and the targeted ...
Hao Sun, Jing Zhang, Ping Gu
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Fundamentals of Intervertebral Disc Degeneration.
World Neurosurgery, 2022Lumbar disc degeneration is one of the leading causes of chronic low back pain. The degenerative cascade is often initiated by an imbalance between catabolic and anabolic processes in the intervertebral discs.
Sertaç Kırnaz +7 more
semanticscholar +1 more source
Expert Opinion on Pharmacotherapy, 2003
The spinocerebellar ataxias (SCA) are a large group of inherited disorders affecting the cerebellum and its afferent and efferent pathways. Their hallmark symptom is slowly progressive, symmetrical, midline, and appendicular ataxia. Some may also have associated hyperkinetic movements (chorea, dystonia, myoclonus, postural/action tremor, restless legs,
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The spinocerebellar ataxias (SCA) are a large group of inherited disorders affecting the cerebellum and its afferent and efferent pathways. Their hallmark symptom is slowly progressive, symmetrical, midline, and appendicular ataxia. Some may also have associated hyperkinetic movements (chorea, dystonia, myoclonus, postural/action tremor, restless legs,
openaire +3 more sources
Continuum, 2010
Frontotemporal degeneration (FTD), one of the most prevalent causes of presenile dementia, includes three subtypes: (1) behavioral variant FTD (bvFTD), (2) semantic variant (SV), and (3) progressive nonfluent aphasia (PNFA). Corticobasal degeneration, progressive supranuclear palsy, and FTD-ALS are linked clinically and pathologically to FTD.
Görsev G, Yener +2 more
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Frontotemporal degeneration (FTD), one of the most prevalent causes of presenile dementia, includes three subtypes: (1) behavioral variant FTD (bvFTD), (2) semantic variant (SV), and (3) progressive nonfluent aphasia (PNFA). Corticobasal degeneration, progressive supranuclear palsy, and FTD-ALS are linked clinically and pathologically to FTD.
Görsev G, Yener +2 more
openaire +2 more sources
Brain, 1989
Three patients with clinical and pathological features of corticobasal degeneration are described. They presented with a progressive disease bearing some clinical resemblance to Steele-Richardson-Olszewski syndrome and displaying some pathological features of Pick's disease.
W R, Gibb, P J, Luthert, C D, Marsden
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Three patients with clinical and pathological features of corticobasal degeneration are described. They presented with a progressive disease bearing some clinical resemblance to Steele-Richardson-Olszewski syndrome and displaying some pathological features of Pick's disease.
W R, Gibb, P J, Luthert, C D, Marsden
openaire +2 more sources

