Results 71 to 80 of about 12,592 (146)

A systematic literature review of spinal brace/orthosis treatment for adults with scoliosis between 1967 and 2018: clinical outcomes and harms data

BMC Musculoskeletal Disorders, 2020
Background There is a paucity of literature regarding the conservative management of adult scoliosis. The authors review and summarize the literature from 1967 to 2018 on the clinical outcomes of spinal brace/orthosis use in this subgroup of the ...
Jeb McAviney, Johanna Mee, Azharuddin Fazalbhoy, Juan Du Plessis, Benjamin T. Brown   +4 more
doaj   +1 more source

The evolving therapeutic landscape of spinal muscular atrophy – A scoping review of investigational agents, emerging delivery technologies and strategic innovations

British Journal of Clinical Pharmacology, Volume 92, Issue 6, Page 1552-1566, June 2026.
Spinal muscular atrophy (SMA) is a severe neuromuscular disease with emerging therapeutic complexity. This review aims to systematically map the global pipeline of investigational treatments for SMA. Using ClinicalTrials.gov and complementary international registries, we identified 21 planned or ongoing interventional trials from 2020 to 2025 targeting
Andrej Belančić, Patrick Eustaquio, Elvira Meni Maria Gkrinia, Ivana Stević, Eugen Javor, Yun Wah Lam, Slobodan Janković, Dinko Vitezić   +7 more
wiley   +1 more source

MRI reveals scoliosis as a silent driver of lumbar facet joint degeneration in aging Ecuadorian adults

Scientific Reports
Lumbar facet arthropathy (LFA) is a degenerative condition of the facet joints that contributes significantly to chronic low back pain (CLBP) yet remains underrecognized in standard diagnostic protocols.
Pablo Cueva-Medina, Jorge Silva-Hidalgo, Fabricio González-Andrade   +2 more
doaj   +1 more source

Comparison between two pedicle screw augmentation instrumentations in adult degenerative scoliosis with osteoporosis

BMC Musculoskeletal Disorders, 2011
Background The operative treatment of adult degenerative scoliosis combined with osteoporosis increase following the epidemiological development. Studies have confirmed that screws in osteoporotic spines have significant lower-screw strength with more ...
Xie Yang, Fu Qiang, Chen Zi-qiang, Shi Zhi-cai, Zhu Xiao-dong, Wang Chuan-feng, Li Ming   +6 more
doaj   +1 more source

A Novel Decomposition‐Based Growth Model for Simulating Stress‐Modulated Spinal Growth

International Journal for Numerical Methods in Biomedical Engineering, Volume 42, Issue 6, June 2026.
This study introduces the first decomposition‐based finite‐strain growth model for a simplified Functional Spinal Unit, where growth occurs simultaneously with mechanical loading. The approach eliminates the major physical inconsistency of sequential methods—growth in an artificial stress‐free configuration—while preventing mesh distortion and ...
Serhat Onur Çakmak, Ercan Gürses
wiley   +1 more source

Genetic Bone Diseases: A Scoping Review of Pathology, Symptoms, Diagnosis, Treatment, and New Horizons

Advanced Genetics, Volume 7, Issue 2, June 2026.
This review highlights six genetic diseases of the bone, aiming to provide clinicians and researchers with updated information on their diagnosis and treatment. It also includes an assessment of common clinical and radiographic findings, along with pathophysiology related to diseases.
Colin Jones, Ambalangodage C. Jayasuriya
wiley   +1 more source

Role of Minimally Invasive Spine Surgery in Adults with Degenerative Lumbar Scoliosis: A Narrative Review

Iranian Journal of Neurosurgery, 2017
Background and Aim: Degenerative lumbar scoliosis is a spinal deformity resulting from advanced disc degeneration and facet arthropathy. Given the inconclusive available literature and lack of high-quality data supporting the role of minimally invasive ...
Tony Tannoury, kaveh haddadi, Harish Kempegowda, Abhijeet Kadam, Chadi Tannoury   +4 more
doaj  

Adjacent segment disease in degenerative pathologies with posterior instrumentation

Coluna/Columna, 2015
OBJECTIVE: To establish the real incidence of adjacent segment disease after fusion, and to identify the levels and predisposing factors for the pathology, as well as the functional results.
Ana Guadalupe Ramírez Olvera, Manuel Villarreal Arroyo, Luis Mario Hinojosa Martínez, Enrique Méndez Pérez, Luis Romeo Ramos Hinojosa   +4 more
doaj   +1 more source

Deletion of a Pax1 Sex‐Associated Genomic Region Associated With Adolescent Idiopathic Scoliosis Leads to Disc Degeneration, Instability, and Vertebral Rotation in Mice

JOR SPINE, Volume 9, Issue 2, June 2026.
Overview of the effects of Pax1‐SAR deletion on gene expression, IVD degeneration, and resultant scoliotic‐like curvature between sexes. Proposed mechanism of sex‐dependent changes in gene expression in females (right) and males (left), resulting in sex‐dependent disc degeneration and scoliotic phenotypes.
Edward C. Moody, Emma M. Wade, Shuji Mizumoto, Jeremy McCallum‐Loudeac, Megan J. Wilson   +4 more
wiley   +1 more source

Lifetime Physical Loading and Magnetic Resonance‐Derived Intervertebral Disc Health in Adults With Chronic Low Back Pain: A Cross‐Sectional Study

JOR SPINE, Volume 9, Issue 2, June 2026.
Final multiple linear regression model: heat maps showing Bone‐specific Physical Activity Questionnaire score associations with T2 values in five intervertebral disc (IVD) regions with statistically significant covariates controlled for at individual spinal levels.
Claire L. Samanna, Christopher Neason, Scott D. Tagliaferri, Ulrike H. Mitchell, Michelle Caldwell, Ali Imran, Hana Rae Nez, Daniel L. Belavý, Clint T. Miller, David Scott, Niamh L. Mundell, Paul Buntine, Patrick J. Owen   +12 more
wiley   +1 more source