Results 161 to 170 of about 22,980 (334)

Chemical Components of the Dried Latex of Euphorbia resinifera Berg and Its Medicinal Features

open access: yesChemistry &Biodiversity, EarlyView.
ABSTRACT A great deal of research has been carried out on the latex of Euphorbia resinifera Berg, which is an important source of several compounds of therapeutic and medicinal interest. Extraction, synthesis, and hemi synthesis pathways continue to reveal the existence of other new products with anticancer, antioxidant, antidiuretic, and antimalarial ...
Doaa Hammad   +5 more
wiley   +1 more source

PLK4: Master Regulator of Centriole Duplication and Its Therapeutic Potential

open access: yesCytoskeleton, EarlyView.
ABSTRACT Centrosomes catalyze the assembly of a microtubule‐based bipolar spindle, essential for the precise chromosome segregation during cell division. At the center of this process lies Polo‐Like Kinase 4 (PLK4), the master regulator that controls the duplication of the centriolar core to ensure the correct balance of two centrosomes per dividing ...
Muhammad Hamzah   +2 more
wiley   +1 more source

Predicting Maternal and Fetal Exposures of Elexacaftor–Tezacaftor–Ivacaftor during Pregnancy through Physiologically Based Pharmacokinetic Models

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
The use of elexacaftor/tezacaftor/ivacaftor (ETI) has been associated with increased fertility in women with cystic fibrosis (CF) and is increasingly used during pregnancy to support both maternal and fetal health. However, little is known about the pharmacokinetics (PK) of ETI during pregnancy, which is crucial for optimizing its efficacy and safety ...
Eunjin Hong   +8 more
wiley   +1 more source

Screening and Quantification of the Synthetic Cannabinoid Receptor Agonist 5F‐MDMB‐PINACA From Seized Prison Paper Using Ultraperformance Liquid Chromatography–Mass Spectrometry Approaches

open access: yesDrug Testing and Analysis, EarlyView.
Synthetic cannabinoid receptor agonists are being infused on paper and illicitly introduced into prisons through mail correspondence. An approach to quantify and map the synthetic cannabinoid 5F‐ADB on a seized paper sample from a UK prison was determined using ultraperformance liquid chromatography–quadrupole Dalton–mass spectrometry.
Giorgia Vaccaro   +4 more
wiley   +1 more source

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