Results 91 to 100 of about 2,866,287 (294)

PLK4: Master Regulator of Centriole Duplication and Its Therapeutic Potential

Cytoskeleton, EarlyView.
ABSTRACT Centrosomes catalyze the assembly of a microtubule‐based bipolar spindle, essential for the precise chromosome segregation during cell division. At the center of this process lies Polo‐Like Kinase 4 (PLK4), the master regulator that controls the duplication of the centriolar core to ensure the correct balance of two centrosomes per dividing ...
Muhammad Hamzah, Franz Meitinger, Midori Ohta   +2 more
wiley   +1 more source

Clinically Important Endpoints in Individuals With Leukodystrophy: A Multisite Study

Annals of the Child Neurology Society, EarlyView.
ABSTRACT Importance Leukodystrophies are a diverse group of rare disorders that disrupt central myelination. These disorders present with a broad spectrum of neurological severity and are associated with a range of potential secondary complications, such as scoliosis and failure of independent feeding.
Emma R. Kotes, Sarah Woidill, Russell D'Aiello, Amina Khan, Jacob McCann, Mark Ramos, Francesco Gavazzi, Stephanie Keller, Keith Van Haren, Ali Fatemi, Florian Eichler, Joshua Bonkowsky, Jamie Fraser, Lisa Emrick, Omar Sherbini, Ashley Hackett, Jeilo Gauna, Dandre Amos, Jordan Goodman, Amena Smith Fine, Amanda Nagy, Seungil Lee, Nicole Page, Johanna Schmidt, Amy Pizzino, Kayla Muirhead, Mariko Bennett, Amy Waldman, Justine Shults, Laura Adang, Robert Grundmeier, Adeline Vanderver   +31 more
wiley   +1 more source

The Prevalence of Dysphagia in Children with Laryngomalacia Pre and Postsupraglottoplasty: A Systematic Review with Meta-Analysis

International Archives of Otorhinolaryngology
Introduction Laryngomalacia is the most common congenital laryngeal alteration, with spontaneous resolution in most cases. However, in the face of more severe presentations of the disease, it is necessary to perform supraglottoplasty ...
Eduarda Pinto Rossoni, Vanessa Souza Gigoski de Miranda, Lisiane De Rosa Barbosa   +2 more
doaj   +1 more source

Taste Profile and Relative Bioavailability of Tovorafenib Powder for Oral Suspension and Food Effect of the Tovorafenib Tablet in Healthy Participants

Clinical Pharmacology in Drug Development, EarlyView.
Abstract A pediatric‐friendly powder for oral suspension (PfOS) of tovorafenib, a type II RAF inhibitor, was developed for patients with difficulty swallowing tablets. This open‐label, randomized, phase 1 study (QSC205140) evaluated the taste/palatability of PfOS formulations (n = 12), the relative bioavailability of the PfOS versus tablet formulation,
Yang Zhang, Mike Preigh, Jing Wang, Eleni Venetsanakos, Yujin Wang, Elly Barry, Don Corson   +6 more
wiley   +1 more source

Ictal semiology in anterior cingulate epilepsy: A systematic review

Epileptic Disorders, EarlyView.
Abstract Seizures originating from the anterior cingulate cortex (ACC) have distinct clinical features but can be difficult to identify in frontal lobe epilepsy (FLE). This systematic review examines the key semiology of ACC seizures and their anatomical correlations.
Francine Chassoux, Eve Sallèles, Yohan Caudron, Adrien Zanin, Agathe Laurent, Dorottya Cserpan, Georgia Ramantani   +6 more
wiley   +1 more source

Clinical observation on acupoint massage plus Vitalstim electrical stimulation for deglutition disorder after stroke [PDF]

, 2020
Li Tian, Shao-tong Nie, Tian-xiao Lou, Huan Chen, Yuan Guang-hui   +4 more
openalex   +1 more source

Rest‐activity rhythm phenotypes in adults with epilepsy and intellectual disability

Epilepsia Open, EarlyView.
Abstract Objective Rest‐activity rhythms (RARs) are perturbed in many forms of neuropsychiatric illness. In this study, we applied wrist actigraphy to describe RAR perturbations in intellectually disabled adults with epilepsy (“E + ID”), using a cross‐sectional case–control design.
Nandani Adhyapak, Grace E. Cardenas, Mark A. Abboud, Vaishnav Krishnan   +3 more
wiley   +1 more source

Extracellular Vesicle‐Based mRNA Therapeutics and Vaccines

Exploration, EarlyView.
This review provides a comprehensive analysis of recent advancements in extracellular vesicle (EV)‐based messenger RNA (mRNA) applications for therapeutics and vaccines. It systematically outlines strategies for mRNA encapsulation within EVs and elucidates the challenges associated with this technology, offering insights into future research directions
Qi Li, Haonan Xing, Abid Naeem, Kaiyue Zhang, Aiping Zheng, Yuanyu Huang, Mei Lu   +6 more
wiley   +1 more source

Acoustic Features of Airway Protective Maneuvers as Biomarkers of Radiation‐Associated Dysphagia and Penetration/Aspiration in Head and Neck Cancer Patients

Head &Neck, EarlyView.
ABSTRACT Background This study aimed at identifying acoustic features of airway protective maneuvers as biomarkers of radiation‐associated dysphagia, involving penetration/aspiration and pharyngeal residue. Methods Temporal and spectral acoustical analyses were carried out on voluntary coughs, voluntary throat clearings, and reflexive coughs.
Sofiana Mootassim‐Billah, Jean Schoentgen, Marc De Bodt, Hichem Slama, Esther Willemse, Tatiana Dragan, Nicolas Roper, Mathilde Le Tensorer, Paulus Kristanto, Marianne Paesmans, Dirk Van Gestel, Gwen Van Nuffelen   +11 more
wiley   +1 more source

Partial Laryngectomy for Thyroid Cancer: A Single Institution Case Series With Operative Techniques

Head &Neck, EarlyView.
ABSTRACT Background Partial laryngectomy has been well described as a management option for T1–3 laryngeal squamous cell cancers. However, there are a few case reports of partial laryngeal surgery for locally advanced thyroid carcinoma. Methods This is a case series of five patients with thyroid carcinoma (one primary and four recurrent) with laryngeal
Ella E. Hawes, Victoria E. Banuchi, Anastasios Maniakas, Jennifer R. Wang, Paul H. Graham, Julia D. Diersing, Naifa L. Busaidy, Maria E. Cabanillas, Ramona Dadu, Sarah Hamidi, Priyanka Iyer, Steven G. Waguespack, Salmaan Ahmed, Sahar Alizada, Alexandra Belcastro, Ranim Alsharif, Mimi I. Hu, Mark E. Zafereo   +17 more
wiley   +1 more source