Results 51 to 60 of about 149 (146)

Correlations between Dysphagia Severity Scale Scores and Clinical Indices in Individuals with Multiple System Atrophy

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Dysphagia significantly impacts prognosis in individuals with multiple system atrophy (MSA). While video‐based assessments are practical, their limited availability highlights the need for a simple tool such as the Dysphagia Severity Scale (DSS) in clinical practice.
Ryunosuke Nagao, Yasuaki Mizutani, Kazuya Kawabata, Junichiro Yoshimoto, Yoko Inamoto, Seiko Shibata, Mizuki Ito, Yohei Otaka, Hirohisa Watanabe   +8 more
wiley   +1 more source

Progranulin Mutation Manifesting as Parkinson Disease: A Case Series from the PADUA‐CESNE Cohort

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Mutations in progranulin (GRN) are associated with frontotemporal dementia, although a Parkinson disease (PD) phenotype is uncommon, especially in young patients. Cases We report three subjects from the PADUA‐CESNE cohort, meeting diagnostic criteria for PD, with onset under age 55.
Giulia Bonato, Marta Campagnolo, Aron Emmi, Valentina Misenti, Tommaso Carrer, Carmelo Fogliano, Leonardo Salviati, Miryam Carecchio, Angelo Antonini   +8 more
wiley   +1 more source

Association between Perceived Dysphagia Symptoms and Swallowing Physiology in Parkinson's Disease

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Swallowing disorders are prevalent in Parkinson's disease (PD). Swallowing assessment often relies on patient‐reported outcome measures (PROMs). Although PROMs and physiologic swallowing measures correlate with disease severity, the relationship between PROMs and physiologic swallowing impairments is unclear.
Rabab Rangwala, Mariana Mendes Bahia, Jing Song, Danny Bega, Bonnie Martin‐Harris   +4 more
wiley   +1 more source

Long‐Term Outcomes on Pallidal Neurostimulation for Dystonia: A Controlled, Prospective 10‐Year Follow‐Up

Movement Disorders, EarlyView.
Abstract Background Pallidal neurostimulation is an effective treatment for severe isolated dystonia, but long‐term data from clinical trials are lacking. Objectives To evaluate long‐term efficacy and safety of pallidal neurostimulation in patients with isolated generalized or segmental dystonia.
Patricia Krause, Philipp Mahlknecht, Inger Marie Skogseid, Frank Steigerwald, Günther Deuschl, Richard Erasmi, Alfons Schnitzler, Tobias Warnecke, Jörg Müller, Werner Poewe, Gerd‐Helge Schneider, Jan Vesper, Nils Warneke, Wilhelm Eisner, Thomas Prokop, Jan‐Uwe Müller, Jens Volkmann, Andrea A. Kühn, for the Deep‐Brain Stimulation for Dystonia Study Group, Maximilian Mehdorn, Patricia Krause, Doreen Gruber, Anatol Kivi, Andreas Kupsch, Bianca Müller, Gerd‐Helge Schneider, Alfons Schnitzler, Volker Sturm, Lars Timmermann, Jürgen Voges, Lars Wojtecki, Guido Nikkah, Markus Pinsker, Thomas Prokop, Jan Vesper, Manja Kloss, Martin Krause, Volker Tronnier, Wilhelm Eisner, Thomas Fiegele, Jörg Müller, Sasha Hering, Werner Poewe, Günther Deuschl, Jan Herzog, Marcus O Pinsker, Monika Pötter‐Nerger, Frank Steigerwald, Hans‐Werner Boothe, Angela Brentrup, Juliane Vollmer‐Haase, Inger Marie Skogseid, Geir Ketil Roeste, Jan‐Uwe Müller, Matthias Wittstock, Alexander Wolters, Joseph Classen, Markus Naumann, Alex Schramm, Jens Volkmann, Andrea A. Kühn   +60 more
wiley   +1 more source

Nocebo Hypothesis Cognitive Behavioral Therapy for Functional Neurological Symptom Disorder (Motor Type): A Pilot Randomized Controlled Trial

Movement Disorders, EarlyView.
Abstract Background A previous case series showed that Nocebo Hypothesis Cognitive Behavioral Therapy (NH‐CBT) is a promising treatment for Functional Neurological Symptom Disorder (FNSD). Objectives To further evaluate the potential efficacy of NH‐CBT in participants with FNSD (motor type).
Matt Richardson, Maria Kleinstäuber, Dana Wong   +2 more
wiley   +1 more source

Misophonia in Tic Disorders and Their Neuropsychiatric Associations

Movement Disorders Clinical Practice, EarlyView.
Arjun Balachandar, Talyta Cortez Grippe, Wei Kang Lim, Irene A. Malaty, Anthony E. Lang, Christos Ganos   +5 more
wiley   +1 more source

A Systematic Review of Attributes Influencing Preferences for Treatments and Interventions in People With Amyotrophic Lateral Sclerosis (ALS)

Muscle &Nerve, EarlyView.
ABSTRACT Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that has no cure, and treatments predominantly focus on improving quality of life. Patient‐centred care is central to bringing about meaningful improvements to quality of life.
A. Clift, D. Rowen, L. Knox, A. W. Griffiths, C. J. McDermott   +4 more
wiley   +1 more source

Clinical Outcomes with Prospective Brain Sensing Data Following Bilateral Globus Pallidus Deep Brain Stimulation in X‐Linked Dystonia Parkinsonism

Movement Disorders Clinical Practice, EarlyView.
Eoghan Donlon, Clodagh O'Keeffe, Jack Horan, Frederica Ruggieri, Jessica Fitzpatrick, Michael O'Neill, Michael Alexander, Conor Fearon, Catherine Moran, Richard A. Walsh   +9 more
wiley   +1 more source

A Phase 1, Double‐Blind, Placebo‐Controlled Trial of Sevasemten (EDG‐5506), a Selective Modulator of Fast Skeletal Muscle Contraction, in Healthy Volunteers and Adults With Becker Muscular Dystrophy

Muscle &Nerve, EarlyView.
ABSTRACT Introduction/Aims Sevasemten (EDG‐5506) is an orally administered, investigational small molecule that selectively modulates fast muscle fiber contraction by inhibiting fast myosin ATPase. This study assessed the safety, tolerability, and pharmacokinetics (PK)/pharmacodynamics (PD) of sevasemten in healthy adult volunteers (HVs) and adults ...
Joanne Donovan, Jeffrey A. Silverman, Ben Barthel, Michael DuVall, Molly Madden, James MacDougall, Nicole Rempel Kilburn, Abby Bronson, Marc Evanchik, Gilad Gordon, Kevin Koch, Alan J Russell   +11 more
wiley   +1 more source

Improved Pharyngeal Contraction and Oral Intake Status After Modified Central‐Part Laryngectomy for Late‐Stage ALS

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective To investigate the effects of modified central‐part laryngectomy with pharyngeal space reduction (CPL‐PR) on patients with weak deglutitive pharyngeal contraction, as seen in late‐stage amyotrophic lateral sclerosis (ALS). Study Design Retrospective case series. Setting Single‐institution academic center.
Rumi Ueha, Maria Angela Dealino, Misaki Koyama, Kaoru Yamakawa, Naoyuki Matsumoto, Taku Sato, Takao Goto, Aiko Mizukami, Kenji Kondo   +8 more
wiley   +1 more source