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Lifitegrast Degradation: Products and Pathways. [PDF]
Background/Objectives: Lifitegrast is a recent therapeutic agent provoking scientific and regulatory interest due to its outstanding safety profile and high efficacy in the treatment of dry eye disease. Methods: Herein we employ NMR spectroscopy and mass spectrometry to investigate the weak spots of lifitegrast under standard to extreme stress ...
Štefan L +10 more
europepmc +5 more sources
Photo-catalytic Degradation of Chlorendic Acid: 1. Degradation Products [PDF]
The photo-catalytic degradation of chlorendic acid in the presence of TiO2 was conducted to investigate the reaction pathways and possible degradation products as a means of assessing the environmental legacies of polyesters that are designed with both ...
N Boisa
doaj +5 more sources
Research on detection methods of related substances and degradation products of the antitumor drug selpercatinib [PDF]
BackgroundSelpercatinib, a selective RET kinase inhibitor, is approved for treating various cancers with RET gene mutations such as RET-rearranged thyroid cancer and non-small cell lung cancer.
Jingjing Xiang +4 more
doaj +2 more sources
Degradation of 17 Benzodiazepines by the UV/H2O2 Treatment
Benzodiazepines are one group of psychoactive drugs widely detected in water environments, and their persistence during conventional wastewater treatment has raised great concerns. Here we investigated the degradation of 17 benzodiazepines in water by UV/
Wen-Dan You +13 more
doaj +1 more source
Comparison between Chemical and Biological Degradation Processes for Perfluorooctanoic Acid
Perfluorooctanoic acid (PFOA) is a perfluoro compound that contains an eight-carbon perfluoroalkyl chain followed by a carboxylic acid function group. The C-F bound possesses a strong bond energy of approximately 485 kJ/mol, rendering PFOA thermally and ...
Xuhan Shu +3 more
doaj +1 more source
Nirmatrelvir is an antiviral drug approved for the treatment of COVID-19. The available dosage form consists of tablets marketed under the brand name PAXLOVID®.
Philippe-Henri Secretan +9 more
doaj +1 more source

