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Lifitegrast Degradation: Products and Pathways. [PDF]

open access: yesPharmaceutics
Background/Objectives: Lifitegrast is a recent therapeutic agent provoking scientific and regulatory interest due to its outstanding safety profile and high efficacy in the treatment of dry eye disease. Methods: Herein we employ NMR spectroscopy and mass spectrometry to investigate the weak spots of lifitegrast under standard to extreme stress ...
Štefan L   +10 more
europepmc   +5 more sources

Photo-catalytic Degradation of Chlorendic Acid: 1. Degradation Products [PDF]

open access: yesJournal of Applied Sciences and Environmental Management, 2013
The photo-catalytic degradation of chlorendic acid in the presence of TiO2 was conducted to investigate the reaction pathways and possible degradation products as a means of assessing the environmental legacies of polyesters that are designed with both ...
N Boisa
doaj   +5 more sources

Research on detection methods of related substances and degradation products of the antitumor drug selpercatinib [PDF]

open access: yesFrontiers in Chemistry
BackgroundSelpercatinib, a selective RET kinase inhibitor, is approved for treating various cancers with RET gene mutations such as RET-rearranged thyroid cancer and non-small cell lung cancer.
Jingjing Xiang   +4 more
doaj   +2 more sources

Degradation of 17 Benzodiazepines by the UV/H2O2 Treatment

open access: yesFrontiers in Environmental Science, 2021
Benzodiazepines are one group of psychoactive drugs widely detected in water environments, and their persistence during conventional wastewater treatment has raised great concerns. Here we investigated the degradation of 17 benzodiazepines in water by UV/
Wen-Dan You   +13 more
doaj   +1 more source

Comparison between Chemical and Biological Degradation Processes for Perfluorooctanoic Acid

open access: yesSoil Systems, 2023
Perfluorooctanoic acid (PFOA) is a perfluoro compound that contains an eight-carbon perfluoroalkyl chain followed by a carboxylic acid function group. The C-F bound possesses a strong bond energy of approximately 485 kJ/mol, rendering PFOA thermally and ...
Xuhan Shu   +3 more
doaj   +1 more source

Unequal Behaviour between Hydrolysable Functions of Nirmatrelvir under Stress Conditions: Structural and Theoretical Approaches in Support of Preformulation Studies

open access: yesPharmaceutics, 2022
Nirmatrelvir is an antiviral drug approved for the treatment of COVID-19. The available dosage form consists of tablets marketed under the brand name PAXLOVID®.
Philippe-Henri Secretan   +9 more
doaj   +1 more source

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