Results 151 to 160 of about 7,058,514 (292)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Assessment of planting soil temperature and growing degree day impacts on silage corn (Zea mays L.) biomass. [PDF]

J Anim Sci Technol
Kim M, Kim J, Jo MH, Sung K, Han KJ.
europepmc   +1 more source

Estimating West Nile virus transmission period in Pennsylvania using an optimized degree-day model. [PDF]

Vector Borne Zoonotic Dis, 2013
Chen S, Blanford JI, Fleischer SJ, Hutchinson M, Saunders MC, Thomas MB.   +5 more
europepmc   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Biology, temperature thresholds, and degree-day requirements for development of the cucumber moth, Diaphania indica, under laboratory conditions. [PDF]

J Insect Sci, 2014
Hosseinzade S, Izadi H, Namvar P, Samih MA.   +3 more
europepmc   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Hobo Day Button, 1957

, 1957
Hobo Day button, alternating blue and yellow for background and lettering - scene with Weary Will and University of South Dakota Coyotes mascot - text reads '46th Annual Hobo Day, Oct.
Hobo Day Committee (South Dakota State University)
core  

On accumulated degree day and maggot age calculations in Rivers and Dahlem (2023) The Science of Forensic Entomology, 2nd edition. [PDF]

J Med Entomol
Wells JD.
europepmc   +1 more source

Cautioning the use of degree-day models for climate change projections in the presence of parametric uncertainty. [PDF]

Ecol Appl, 2012
Moore JL, Liang S, Akullian A, Remais JV.   +3 more
europepmc   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source