Results 111 to 120 of about 323,104 (281)

Aberrant degree centrality profiles during rumination in major depressive disorder. [PDF]

Hum Brain Mapp, 2023
Jia FN, Chen X, Du XD, Tang Z, Ma XY, Ning TT, Zou SY, Zuo SF, Li HX, Cui SX, Deng ZY, Fu JL, Fu XQ, Huang YX, Li XY, Lian T, Liao YF, Liu LL, Lu B, Wang Y, Wang YW, Wang ZH, Ye G, Zhang XZ, Zhu HL, Quan CS, Sun HY, Yan CG, Liu YS.   +28 more
europepmc   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

On the sensitivity of centrality metrics.

PLoS ONE
Despite the huge importance that the centrality metrics have in understanding the topology of a network, too little is known about the effects that small alterations in the topology of the input graph induce in the norm of the vector that stores the node
Lucia Cavallaro, Pasquale De Meo, Giacomo Fiumara, Antonio Liotta   +3 more
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Isolating Coefficient-Based Framework to Recognize Influential Nodes in Complex Networks

IEEE Access
Identifying influential nodes within complex networks holds significant importance for enhancing network resilience and understanding vulnerabilities, thereby providing insights for both theoretical exploration and practical applications.
Buran Basha Mohammad, V. Sateeshkrishna Dhuli, Murali Krishna Enduri, Linga Reddy Cenkeramaddi   +3 more
doaj   +1 more source

The critical node detection problem in hypergraphs using weighted node degree centrality. [PDF]

PeerJ Comput Sci, 2023
Képes TZ.
europepmc   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Aberrant voxel-based degree centrality and functional connectivity in Parkinson's disease patients with fatigue. [PDF]

CNS Neurosci Ther, 2023
Shan A, Zhang H, Gao M, Wang L, Cao X, Gan C, Sun H, Yuan Y, Zhang K.   +8 more
europepmc   +1 more source