Results 41 to 50 of about 47,285 (309)

A Patient‐Derived Organoid Biobank of Adamantinomatous Craniopharyngioma as a Platform for Drug Discovery

Advanced Science, EarlyView.
This study successfully establishes adamantinomatous craniopharyngioma (ACP) patient‐derived organoids (PDOs) that preserve the histopathological and genetic features of the original tumors. Through drug sensitivity assays and subsequent mechanistic analyses, the study demonstrates that Ceritinib exerts its inhibitory effects on ACP PDO growth by ...
Huarong Zhang, Chaohu Wang, Jun Fan, Zexin Chen, Haoying Yu, Yawen Bai, Tingcheng Zhang, Qianchao Zhu, Yiwen Feng, Peirong Niu, Jiaqian Chen, Liping Yang, Xueying Li, Lei Yu, Songtao Qi, Yi Liu   +15 more
wiley   +1 more source

The Geometry of Layer 2/3 Cortical Sound Processing in Slow Wave Sleep

Advanced Science, EarlyView.
Sleep is associated with a sensory disconnection whose mechanisms remain elusive. Large neuronal population recordings in the auditory cortex revealed that, in NREM sleep, the neural code for sounds is highly similar to wakefulness, but coordinated modulations of neuron responsiveness intermittently disconnect the local cortical networks from sensory ...
Allan Muller, Anton Filipchuk, Sophie Bagur, Brice Bathellier   +3 more
wiley   +1 more source

Relationships Between Music and Empathic Decision Making in Healthy Young Adults

Music & Science, 2021
Music and empathy are components of social experience. Similar and adjacent functional brain systems are required in the production and understanding of music, the processing of emotion, and engagement in social behavior.
Aaron Colverson, Damon Lamb, Cyndi Garvan, Kok-Ben Toh, Eric Porges, Welson Tremura, John Williamson   +6 more
doaj   +1 more source

A Virtual Clinical Trial of Psychedelics to Treat Patients With Disorders of Consciousness

Advanced Science, EarlyView.
Disorders of consciousness after severe brain injury are marked by reduced complexity of brain activity and limited treatment options. Using personalized whole‐brain models, this study shows that simulated lysergic acid diethylamide (LSD) and psilocybin shift patient brain dynamics closer to criticality.
Naji L.N. Alnagger, Paolo Cardone, Charlotte Martial, Yonatan Sanz Perl, Iván Mindlin, Jacobo D Sitt, Leor Roseman, Robin Carhart‐Harris, David Nutt, Pablo Mallaroni, Natasha Mason, Johannes G Ramaekers, Vincent Bonhomme, Steven Laureys, Gustavo Deco, Olivia Gosseries, Pablo Núñez, Jitka Annen   +17 more
wiley   +1 more source

The Development of University Music Education in Nigeria: An Outline

SAGE Open, 2018
University music education is a recent phenomenon in Nigeria. The founding of the University of Nigeria, Nsukka, with autonomy to grant degrees for courses in nearly all fields of study, enabled it to initiate music degree along the lines of the Euro ...
Adebowale Oluranti Adeogun
doaj   +1 more source

Near‐Field Acoustic Imaging Using Fiber‐Optic Distributed Acoustic Sensing and Beamforming Techniques

Advanced Science, EarlyView.
This work introduces a beamforming‐based method to generate acoustic images from fiber‐optic distributed acoustic sensing (DAS) data. By performing 2D scanning around the sensing fiber, the approach enables near‐field imaging and localization of acoustic sources, even in regions distant from the fiber. A data‐driven DAS channel selection improves image
Marcelo A. Soto, Diego Badillo‐San‐Juan   +1 more
wiley   +1 more source

Concert Music: a debt to future generations

Revista MENDIVE, 2013
This article begins with the conceptualization of music, and within it the concert music as one of the most reviled generic types of the history of music.
Katia Morales Pérez, Naiby Puente Barroso, Yovany Álvarez García   +2 more
doaj  

Light Therapy Alleviates Addiction‐Related Symptoms and Reshapes Habenula and Midbrain Pathways

Advanced Science, EarlyView.
This study investigates light therapy for treating Internet Gaming Disorder (IGD). Functional MRI (fMRI) data reveal that light therapy enhances brain connectivity, particularly between the habenula and the medial orbitofrontal cortex (mOFC). These changes are associated with reduced withdrawal symptoms and addiction severity, highlighting the ...
Jinhui Li, Huiyang Huang, Cunhao Hu, Xuan Zhang, Song Lin, Xiaodan Huang, Ti‐fei Yuan, Kwok‐Fai So, Lu Huang, Chaoran Ren, Qian Tao   +10 more
wiley   +1 more source

scPER: A Rigorous Computational Approach to Determine Cellular Subtypes in Tumors Aligned With Cancer Phenotypes From Total RNA Sequencing

Advanced Science, EarlyView.
scPER presents an adversarial‐autoencoder framework that deconvolves bulk total RNA‐seq to quantify tumor‐microenvironment cell types and uncover phenotype‐linked subclusters. Across diverse benchmarks, scPER improves accuracy over existing tools.
Bingrui Li, Xiaobo Zhou, Raghu Kalluri
wiley   +1 more source

Efficacy of Music Therapy on Immediate Postpartum Episiotomy Pain: A randomized controlled trial

Thai Journal of Obstetrics and Gynaecology, 2018
Objectives: To evaluate the effectiveness of music therapy in alleviating immediate postpartum episiotomy wound pain. Materials and Methods: A randomized controlled trial was conducted to evaluate the efficacy of music therapy in ...
Ravita Chaichanalap, Wipada Laosooksathit, Kittipong Kongsomboon, Tharangrut Hanprasertpong   +3 more
doaj   +1 more source