Results 141 to 150 of about 167,528,363 (247)

Comparative analysis of two-dimensional and three-dimensional machine learning models for predicting the degree of invasion in lung non-mucinous adenocarcinomas presenting as subsolid nodules. [PDF]

Front Oncol
Hui YM, Lin MZ, Li B, Meng YQ, Feng HM, Chen YZ, Su ZP.   +6 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Banking industry's consolidation: what's a small business to do? [PDF]

Relaxation of the rules governing where banks can expand and new technologies for providing banking services have contributed to rapid consolidation in the industry. In addition, the number of commercial banks in the United States has been shrinking, and
Loretta J. Mester
core  

Lung Ultrasound-Guided Non-Fiberobronchoscopic Bronchoalveolar Lavage for Neonatal Atelectatic Pulmonary Disease Treatment: Clinical Practice Guidelines Based on International Expert Consensus. [PDF]

Diagnostics (Basel)
Liu J, Guo YL, Jiang P, Zhang X, Deng BY, Liu ZJ, Wang XX, Hong Y, Ren XL, Zhao MR, Li N, Xie CX, Meng Q, You CM, Liang ZY, Shan RY, Cen JG, Li S, Wang WP, Zang LL, Wang YJ, Liu L, Fu W, Ye YN, Li XX, Bao LY, Feng ZL, Maimaitili A, Sorantin E, Hsieh KS, Kurepa D, Lovrenski J, Kruczek P, Nobile S, Yeh TF, Volpicelli G, Suryawanshi P, Lodha A, Singh Y, On Behalf Of The Paediatric Medicine Branch Of Asia-Pacific Health Association, The Neonatal Critical Care Medicine Branch Of Beijing Association Of Holistic Integrative Medicine, The Lung Ultrasound Technology Extension Expert Group Of China National Health Association.   +41 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Early Structural Lung Changes in Primary Ciliary Dyskinesia (PCD). [PDF]

Pediatr Pulmonol
Robinson P, Yokote M.
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Other titles: Chapter 2, Education Consolidation and Improvement Act, evaluation Chapter two, ECIA, evaluation

, 1986
"April 15, 1986." Report covers State Fiscal Year from July 1 to June 30."The Education Consolidation and Improvement Act (ECIA) of 1981 consolidated a number of previously separate programs which provide Federal aid to elementary and secondary education
Kansas. State Department of Education.
core  

Influence of Southeast China's seawater chemistry on the performance development of cement-sodium silicate grout. [PDF]

Sci Rep
Dai H, Wang L, Wang Q, Li L, Zhou Z, Zhang C, Bai T, Liu H, Gao H, Wang H, Zheng B.   +10 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source