Results 111 to 120 of about 380,117 (282)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Coverage control strategy for directional sensor networks

Tongxin xuebao, 2011
Aimed at disadvantages on most existing coverage control algorithms for directional sensor networks,such as finite orientations,the restrained degree of optimization,the deficient applicability of these algorithms etc.,a coverage control strategy（CCS ...
LI Jing, WANG Ru-chuan, HUANG Hai-ping, SUN Li-juan, XIAO Fu, JIANG Ling-yun   +5 more
doaj   +2 more sources

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Exploring the Cross-Sectoral Joint Fire Management Mode Driven by Fire Information in China: From the Perspective of Organizational Interaction

Fire
With the increase in types of fire risk and the expansion of fire management coverage, it is urgent to involve multiple subjects in fire management. Cross-sectoral joint fire management is a new fire management mode based on collaboration between the ...
Yuwei Song, Jida Liu
doaj   +1 more source

TO THE PROBLEM OF SHOT PEENING COVERAGE DEGREE DETERMINATION

Proceedings of Irkutsk State Technical University, 2017
Vladimir P. Koltsov, Le Tri Vinh, Daria A. Starodubtseva   +2 more
openaire   +1 more source

Initial degree of detaching bubble adsorption coverage and the kinetics of dynamic adsorption layer formation.

Physical Chemistry, Chemical Physics - PCCP, 2018
D. Kosior, J. Zawała
semanticscholar   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Extensive Phylogenetic Analysis of a Soil Bacterial Community Illustrates Extreme Taxon Evenness and the Effects of Amplicon Length, Degree of Coverage, and DNA Fractionation on Classification and Ecological Parameters

Applied and Environmental Microbiology, 2008
S. Morales, Ted Cosart, Jesse Johnson, W. Holben   +3 more
semanticscholar   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Surface visualization at 3D endoluminal CT colonography: degree of coverage and implications for polyp detection.

Gastroenterology, 2006
P. Pickhardt, A. Taylor, D. Gopal
semanticscholar   +1 more source