Results 31 to 40 of about 167,483,637 (257)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Travelling solitary waves in the discrete nonlinear Schrodinger equation with saturable nonlinearity: existence, stability and dynamics [PDF]

, 2007
The present work examines in detail the existence, stability and dynamics of travelling solitary waves in dynamical lattices with saturable nonlinearity.
Melvin, TRO., Kevrekidis, PG., Cuevas, J., J. Cuevas, Cuevas-Maraver, Jesús, Cuevas, J, T.R.O. Melvin, Melvin, Thomas R.O., Kevrekidis, PG, Champneys, AR, Melvin, TRO, Champneys, A. R., P.G. Kevrekidis, Kevrekidis, Panayotis G., A.R. Champneys   +14 more
core   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

LiNLNet: Gauging required nonlinearity in deep neural networks

APL Machine Learning, 2023
Feedforward deep neural networks (DNNs) commonly involve layer-wise linear operations and subsequent nonlinear operations, which are repeated through all layers.
SeongMin Jin, Doo Seok Jeong
doaj   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

A new p-y model for soil-pile interaction analyses in cohesionless soils under monotonic loading

Soils and Foundations
The most widely used analysis method for the laterally loaded pile problem is the Winkler spring approach. Although researchers have proposed nonlinear formulations for the p-y curves, the contribution of the soil nonlinearity has not been thoroughly ...
Ozan Alver, E. Ece Eseller-Bayat
doaj   +1 more source

Investigation of Some Cryptographic Properties of the 8x8 S-boxes Created by Quasigroups [PDF]

Computer Science Journal of Moldova, 2020
We investigate several cryptographic properties in 8-bit S-boxes obtained by quasigroups of order 4 and 16 with several different algebraic constructions.
Aleksandra Mileva, Aleksandra Stojanova, Dusan Bikov, Yunqing Xu   +3 more
doaj  

Critical Parameters and Influence on Dynamic Behaviours of Nonlinear Electrostatic Force in a Micromechanical Vibrating Gyroscope

Shock and Vibration, 2020
The electrostatic force nonlinearity caused by fringe effects of the microscale comb will affect the dynamic performance of the micromechanical vibrating gyroscopes (MVGs).
Shuying Hao, Yulun Zhu, Yuhao Song, Qichang Zhang, Jingjing Feng, Kunpeng Zhang   +5 more
doaj   +1 more source

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source