Results 211 to 220 of about 971,776 (299)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Forensic Validation of the 95K SNP Panel and the Parabon Fx Forensic Analysis Platform for Identification of US Military Unknowns Using Extended Kinship Inference. [PDF]

Genes (Basel)
Thomas JT, Cavagnino CL, Sturk-Andreaggi K, Greytak EM, Demarest JA, Barritt-Ross SM, McMahon TP, Marshall C.   +7 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Dual-targeting phytochemicals Ergosterol and Quercetagetin implicate steroid metabolism-associated pathways in lung and liver cancer models. [PDF]

Front Pharmacol
Chen Y, Wu Y, Moradialvand M, Eladl O, Du S, Yang S, Liu X, Zhang S, Chen J, Zeng J, Su X, Ma H, Lu H, Feng J, Cao J, Zhong L, Wang G, Yang J, Karimi-Maleh H, Makvandi P.   +19 more
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Functions on adjacent vertex degrees of trees with given degree sequence

Open Mathematics, 2014
Wang Hua
doaj   +1 more source

Numerical Simulation of the Effect of Process Parameters on Pass Filling Degree in F-Section Steel Finishing Rolling Process. [PDF]

Materials (Basel)
Duan H, Jin L, Xiao R, Gao Y, Li X, Ding J.   +5 more
europepmc   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Analyzing the Influence of Surgical Sequence on Perioperative Circulating Tumor Cells in Patients with Resectable Non-Small Cell Lung Cancer. [PDF]

Cancer Manag Res
Chen H, He Y, Wang Y, Liu X, Zou G.
europepmc   +1 more source

Graphs Identifiable by Degree Sequence and Chromatic Number

Unigraphs are graphs identifiable up to isomorphism from their degree sequences. Given a class $\mathcal{A}$ of graphs, we define the class of $\mathcal{A}$-unigraphs to be graphs identifiable from degree sequence and membership in $\mathcal{A}$.
Whitman, R.
core