Results 101 to 110 of about 847,355 (293)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Delay spread statistics in vicinity ofsame-frequency repeater

Electronics Letters, 1995
The statistics of the delay spread in a two-path mobile radio environment where every path is subject to log-normal shadowing are derived. The channel profile thus considered consists of two delta functions whose power levels are in addition, correlated. Analytical expressions for the probability density function, the mean and the standard deviation of
K.H. Tsioumparakis, T.L. Doumi, J.G. Gardiner   +2 more
openaire   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Channel characterization in the 5.8GHz band in a suburban area

Journal of Microwaves, Optoelectronics and Electromagnetic Applications, 2014
Based on signal measurements carried out in the 5.8 GHz band, which is reserved for unlicensed WiMAX in Brazil, this paper evaluates narrowband and wideband characteristics on the suburban area of Tanguá city in Rio de Janeiro State.
Wilyam D. T. Meza, Gláucio. L. Siqueira, Leni J. Matos   +2 more
doaj  

Comparison of 28 GHz UMi Street Canyon Measurements With Map-Based Hybrid Channel Model

IEEE Access
The map-based hybrid channel model is one of the candidates for managing stochastic components above millimeter waves. This model has been used in technical reports published by several well-known standardization organizations.
Gilbert Siy Ching, Hirokazu Yamakura, Yoto Emori, Yukiko Kishiki   +3 more
doaj   +1 more source

Hands‐on protocol for preparing water‐soluble fractions from agri‐food samples for NMR‐based metabolomics analysis

FEBS Open Bio, EarlyView.
This research protocol outlines a workflow for nuclear magnetic resonance (NMR)‐based metabolomics in the agri‐food sector. Using two case studies—strawberry leaves (solid matrix) and wine (liquid matrix)—it details the procedures for sample preparation, data acquisition, and processing.
Andrea Fernández‐Veloso, Jaime Hiniesta‐Valero, Alejandra Guerra‐Castellano, Miguel A. De la Rosa, Irene Díaz‐Moreno   +4 more
wiley   +1 more source

Channel Characteristics for Fixed and Portable DTV Reception in a Single Frequency Network

Journal of Microwaves, Optoelectronics and Electromagnetic Applications
This paper presents the propagation channel characteristics of a digital TV single-frequency network (SFN) obtained by carrying out field measurements using two synchronized transmitters. The measurements are performed at 31 reception points using both a
Maurício V. Guerra, Jair L. de A. Filho, Carlos V. Rodriguez Ron, Luiz A. R. da Silva Mello, Pedro V. G. Castellanos   +4 more
doaj   +1 more source

Measurement-Based Delay and Doppler Characterizations for High-Speed Railway Hilly Scenario

International Journal of Antennas and Propagation, 2014
This paper presents results for delay and Doppler spread characterization in high-speed railway (HSR) hilly scenario. To investigate the propagation characteristics in this specific terrain, a measurement campaign is conducted along the “Guangzhou ...
Yan Zhang, Zunwen He, Wancheng Zhang, Limin Xiao, Shidong Zhou   +4 more
doaj   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source