Results 121 to 130 of about 6,478,235 (361)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Delayed diagnosis in a child with strangulated mesenteric hernia

Acute Medicine & Surgery
Background Strangulated intestinal obstruction is a life‐threatening condition that should be considered as a differential diagnosis in children with shock. However, it has pitfalls in diagnosis and can lead to diagnostic errors.
Kenichi Tetsuhara, Kazunobu Nakabayashi, Mamoru Muraoka, Rie Kikuno, Michiko Ueda, Ryo Inoue, Makoto Hayashida   +6 more
doaj   +1 more source

Surgical Removal of a Long-Forgotten, Retained Intravascular Foreign Body: A Case Report and Literature Review

Vascular Specialist International
Intravascular foreign body embolization is a potential complication of any vascular operation. Placement of a central venous catheter (CVC) is a common procedure, especially during surgery, hemodialysis, or in critically ill patients.
Dimitrios A. Chatzelas, Apostolos G. Pitoulias, Georgios V. Tsamourlidis, Theodosia N. Zampaka, Vasiliki-Elisavet P. Stratinaki, Ioanna I. Kiose, Anastasios G. Potouridis, Maria D. Tachtsi, Georgios A. Pitoulias   +8 more
doaj   +1 more source

Characterizing Families of Pediatric Patients with Rare Diseases and Their Diagnostic Odysseys: A Comprehensive Survey Analysis from a Single Tertiary Center in Korea [PDF]

Annals of Child Neurology
Purpose Rare diseases necessitate consistent access to specialized health services. In Korea, despite the growing socioeconomic burden, insufficient comprehensive research is available on patients with rare diseases and their families, particularly ...
Jaeso Cho, Young Shin Joo, Jihoon G. Yoon, Seung Bok Lee, Soo Yeon Kim, Jong Hee Chae, Yong Jin Kwon   +6 more
doaj   +1 more source

Delayed Diagnosis of Tuberculous Arthritis

Japanese Journal of Infectious Diseases, 2005
Monoarticular tuberculosis (TB) affecting the knee is rare in all forms of TB (0.1-0.3%). We present the case of a patient with tuberculous arthritis in whom the diagnosis was belated due to a lack of familiarity with the disease; here, we emphasize the difficulties associated with the diagnosing joint TB.
Hakan, Erdem, Orhan, Baylan, Ismail, Simsek, Ayhan, Dinc, Salih, Pay, Murat, Kocaoglu   +5 more
openaire   +2 more sources

Determinants of delayed diagnosis among pediatric cancer patients from Ayder Comprehensive Specialized Hospital, Mekelle, Northern Ethiopia

BMC Pediatrics, 2019
BackgroundDespite advances in the field of pediatric oncology, cancer remains a leading cause of death in children. The delays in cancer diagnosis may occur throughout the diagnostic pathway.
Alemseged Berhane, Tadele Hailu, Afework Mulugeta   +2 more
semanticscholar   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Emergency Department and Radiological Cost of Delayed Diagnosis of Cannabinoid Hyperemesis

Journal of Addiction, 2019
Background. Chronic cannabis use has become prevalent with decriminalization, medical prescription, and recreational legalization in numerous US states. With this increasing incidence of chronic cannabis use a new clinical syndrome has become apparent in
D. Zimmer, Ross McCauley, V. Konanki, Joseph Dynako, Nuha Zackariya, Faadil Shariff, Joseph B. Miller, S. Binz, M. Walsh   +8 more
semanticscholar   +1 more source

Extra-gonadal germ cell tumour – what about the testis! [PDF]

, 2011
Extra-gonadal germ cell tumours (EGGCT) are rare. Therefore further investigations of the testis is aimed at sourcing a possible primary origin of gonadal tumour. Over the years, various case series on EGGCT have been reported questioning its true nature
Christopher CKH,, Goh EH,, Johann FK,, Praveen S,, Razman J,, Zulkifli MZ,   +5 more
core  

CT/MRI LI-RADS v2017 : review of the guidelines [PDF]

, 2018
The Liver Imaging-Reporting and Data System (LI-RADS or LR) is a classification system for reading and reporting imaging studies in patients with high risk for hepatocellular carcinoma (HCC).

core   +1 more source