Results 141 to 150 of about 6,478,235 (361)

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

The Importance of an Early and Accurate MEN1 Diagnosis

Frontiers in Endocrinology, 2018
Multiple Endocrine Neoplasia type 1 (MEN1) is a rare autosomal dominant inherited condition, causing significant morbidity, and a reduction of life expectancy. A timely and accurate diagnosis of MEN1 is paramount to improve disease outcomes. This enables
Joanne M. de Laat, Rachel S. van Leeuwaarde, Gerlof D. Valk   +2 more
doaj   +1 more source

Delayed Diagnosis of Tandem Spinal Stenosis: A Retrospective Institutional Review

The International Journal of Spine Surgery, 2019
Background: Tandem spinal stenosis (TSS) is defined as simultaneous spinal stenosis in the cervical, thoracic, and/or lumbar regions and may present with both upper and lower motor neuron symptoms, neurogenic claudication, and gait disturbance.
Amit K. Bhandutia, Luke Brown, Alysa B. Nash, Ian Bussey, M. Shasti, E. Koh, Kelley E. Banagan, S. Ludwig, D. Gelb   +8 more
semanticscholar   +1 more source

Enhancing Oncological Care for India's Aging Population: Addressing the Complex Needs of Older Adults With Cancer

Aging and Cancer, EarlyView.
Aging‐associated physiological and molecular alterations pose significant challenges in cancer management among India's elderly. Limited geriatric oncology expertise, financial constraints, and inadequate specialized care exacerbate disparities. Strategic expansion of insurance coverage, integration of palliative care, and infrastructural advancements ...
Nihanthy D. Sreenath, Mathigatta Shivarudraiah S, Rajath Govind, Kaushik M R   +3 more
wiley   +1 more source

Delayed Diagnosis and Complications of Predominantly Antibody Deficiencies in a Cohort of Australian Adults

Frontiers in Immunology, 2018
Background Predominantly antibody deficiencies (PADs) are the most common type of primary immunodeficiency in adults. PADs frequently pass undetected leading to delayed diagnosis, delayed treatment, and the potential for end-organ damage including ...
C. Slade, J. Bosco, Tran Binh Giang, E. Kruse, R. Stirling, P. Cameron, Fiona Hore-Lacy, Michael F. Sutherland, S. Barnes, S. Holdsworth, S. Ojaimi, G. Unglik, J. D. De Luca, Mittal Patel, Jeremy S. McComish, Kymble Spriggs, Y. Tran, Priscilla Auyeung, K. Nicholls, R. O'Hehir, P. Hodgkin, J. Douglass, V. Bryant, M. V. van Zelm   +23 more
semanticscholar   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

Potential Undiagnosed VWD Or Other Mucocutaneous Bleeding Disorder Cases Estimated From Private Medical Insurance Claims

Journal of Blood Medicine, 2020
Robert F Sidonio Jr,1 Ayesha Zia,2 Dana Fallaize3 1Aflac Cancer and Blood Disorders Center, Children’s Healthcare of Atlanta, Emory University, Atlanta, GA, USA; 2Division of Hematology Oncology, University of Texas Southwestern Medical Center ...
Sidonio RF Jr, Zia A, Fallaize D
doaj  

Factors associated with delayed diagnosis of migraine: A hospital-based cross-sectional study

Journal of Family Medicine and Primary Care, 2019
Context: Migraine is common debilitating disorders, affecting 10 to 20% of the world's population. However, proper diagnosis is delayed due to many factors. Aims: To determine various factors associated with delayed diagnosis of migraine.
N. Rai, Ritwa Bitswa, Ruchi Singh, Abhijit P. Pakhre, Dayashankar Parauha   +4 more
semanticscholar   +1 more source

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source

Delayed diagnosis of extrapulmonary tuberculosis presenting as fever of unknown origin in an intermediate-burden country

BMC Infectious Diseases, 2018
BackgroundTuberculosis (TB), especially extrapulmonary tuberculosis (EPTB), is an important cause of fever of unknown origin (FUO) in TB-burdened areas.
Jeong-Han Kim, E. S. Kim, K. Jun, H. Jung, J. Bang, P. Choe, W. Park, K. Song, Hong-Bin Kim, N. Kim, M. Oh, Sang-Won Park   +11 more
semanticscholar   +1 more source