Results 101 to 110 of about 154,529 (215)

MiR-148a-3p regulates the fracture healing process by targeting MAFB

Journal of Orthopaedic Surgery and Research
Background Osteoporotic vertebral fracture (OVF) is an extremely common fragile fracture in the elderly population. Aims To explore the expression changes, clinical significance and mechanism of action of miR-148a-3p in the postoperative healing process ...
Yongheng Li, Shuwei Yang, Ganggang Wang, Yingxuan Huang   +3 more
doaj   +1 more source

LncRNA LINC01123-mediated impaired fracture healing through miR-134-5p/XIAP axis

Journal of Orthopaedic Surgery and Research
Background The prolonged recovery and heightened discomfort associated with delayed fracture healing present substantial clinical challenges. Investigations into lncRNA-mediated pathways may provide novel biological targets for enhancing osseous ...
Song Zhou, ZeWen Zheng, ChuanKai Zhang, Liang Hao, Qiang Chen, Ke Sun, Min Cai   +6 more
doaj   +1 more source

Sensor-validated simulations predict fracture healing outcomes in an ovine model

Results in Engineering
Fracture management remains a significant clinical challenge, with nonunions occurring in approximately 5 % of fractures. In tibial shaft fractures 1 in 4 patients are considered unhealed after 5 months and a reoperation rate of 12 % is reported.
Alicia Feist, Carla Hetreau, Manuela Ernst, Peter Varga, Peter Schwarzenberg   +4 more
doaj   +1 more source

Biophysical Stimulation in Delayed Fracture Healing of Hand Phalanx: A Radiographic Evaluation. [PDF]

Biomedicines, 2022
De Francesco F, Gravina P, Varagona S, Setti S, Gigante A, Riccio M.   +5 more
europepmc   +1 more source

Anti-osteoporosis therapy and fracture healing

, 2014
A number of medications are approved for treatment of osteoporosis. As mode of action usually is anti-catabolic/anti-resorptive or anabolic, it is of interest to know whether these drugs affect not only normal bone remodeling, but also fracture healing ...
Fazzalari, Nicola L., Larsson, Sune,
core   +1 more source

Injection of platelet-rich plasma at the fracture site combined with microfracture surgery for the treatment of delayed fracture healing

[Objective] To report a new technique that combines microfracture surgery under local anesthesia with injection of platelet-rich plasma (PRP) at the fracture site, so as to improve fracture healing rates.
HUANG Xiaowu, LI Xingwang, LI Xiaoqing, TU Junbo   +3 more
core   +1 more source

The relationship between the expression of serum asprosin and miR-21 in patients with osteoporosis and delayed healing after OVCF surgery

Journal of Orthopaedic Surgery
Objective: To explore the relationship between serum asprosin, microRNA-21 (miR-21) expression, and delayed healing after surgery in patients with osteoporotic vertebral compression fractures (OVCF), and to construct a nomogram model.
Gaoming Song, Silong Lin, Xianqi Zhang, Hong Pan   +3 more
doaj   +1 more source

Sequential SDF-1/CGRP-releasing smart composite hydrogel promotes osteoporotic fracture healing by targeting sensory nerve-regulated bone remodeling

Materials Today Bio
Osteoporotic fractures typically exhibit delayed healing due to impaired cell recruitment, chronic inflammation, and disrupted neurovascular signaling. Sensory nerve signaling plays a crucial role in fracture repair, and its deficiency is a significant ...
Yuan Wang, Zhen Pan, Qianliang Wang, Yuexia Shu, Zhenyu Tan, Yujie Chen, Jieming He, Jia Wang, Jielin Wang, Jun Yan   +9 more
doaj   +1 more source

The influence of vitamin D and osteoporosis on fracture healing

, 2022
This thesis starts with a comprehensive review of the literature on the role of vitamin D in fracture healing. Followed by three clinical studies on the prevalence of vitamin D deficiency in fracture patients, risk factors and effect of vitamin D status ...
Gorter, E.A.
core  

Single-cell profiling reveals periosteal signatures of impaired periosteal cells proliferation in a drill-hole model of type 2 diabetes

Cell Communication and Signaling
Type 2 diabetes mellitus (T2DM) is associated with an elevated fracture risk and impaired healing, but the periosteum’s role in delayed repair remains unclear.
Xing Ji, Jiahao Luo, Yangxun He, Xinhua Hu, Taotao Xu, Yuanlong Wang, Sijun Pan, Jiali Yao, Weiwei Hu, Ximei Wu   +9 more
doaj   +1 more source