Results 131 to 140 of about 23,229 (258)

Extracellular vesicles in pharmacology: Innovations in drug delivery and therapeutic applications in cancer

British Journal of Pharmacology, EarlyView.
Extracellular vesicles (EVs) are a diverse population of membrane nanoparticles secreted by nearly all cell types, playing a key role in intercellular communication by transferring bioactive macromolecular cargo. In cancer, EVs shape both the local tumour microenvironment and distant premetastatic niches.
Evangelia Pantazaka, Georgios Sivvas, Evangelia Papadimitriou, Constantinos M. Mikelis   +3 more
wiley   +1 more source

The ongoing oleoylethanolamide story: Therapeutic implications in the control of obesity and its comorbidities

British Journal of Pharmacology, EarlyView.
The global burden of obesity continues to rise, demanding effective pharmacological strategies for individuals in whom prevention alone is insufficient. Recent incretin‐based and multi‐agonist therapies have delivered unprecedented weight loss, demonstrating that the simultaneous modulation of multiple metabolic pathways can optimize body weight ...
Marzia Friuli, Alessia Campagna, Barbara Eramo, Christian Sepe, Annarita Zuena, Silvana Gaetani, Adele Romano   +6 more
wiley   +1 more source

Can Symptoms Predict Delayed Gastric Emptying in Diabetic Patients: A Multicenter Study to Revisit Gastroparesis. [PDF]

J Neurogastroenterol Motil
Chung CS, Hung JS, Hsu MH, Chin NH, Wong MW, Lei WY, Lee TH, Chen HF, Wu YW, Wu JM, Chen KH, Wang WL, Chen CL.   +12 more
europepmc   +1 more source

Adeno-associated virus-9 reverses delayed gastric emptying of solids in diabetic mice. [PDF]

Neurogastroenterol Motil, 2023
Li X, Ji S, Cipriani G, Hillestad ML, Eisenman ST, Barry MA, Nath KA, Linden DR, Wright A, AlAsfoor S, Grover M, Sha L, Hsi LC, Farrugia G.   +13 more
europepmc   +1 more source

KYNU in Gastric Cancer Cells Promotes Tumor Progression by Influencing Macrophage Polarization Via PF4

Cancer Science, EarlyView.
KYNU is upregulated in gastric cancer cells and activates the PI3K/Akt pathway, leading to PF4 secretion. PF4 drives nonclassical macrophage polarization with high expression of S100A8 and MMP7, which promotes tumor proliferation, migration, and invasion while suppressing phagocytosis, thereby accelerating gastric cancer progression.
Xilun Cui, Changfeng Li, Yuanda Liu, Chang Liu, Wei Yang   +4 more
wiley   +1 more source

The effect of Braun enteroenterostomy on delayed gastric emptying after pancreaticoduodenectomy: A prospective study. [PDF]

Ann Hepatobiliary Pancreat Surg
Marimuthu RR, Jena J, Ray Choudhury S, Mohanty SS.   +3 more
europepmc   +1 more source

WDR12 Promotes Glucose Metabolism via PFKFB4 Upregulation in Gastric Cancer

Cancer Science, EarlyView.
WDR12 promotes glucose metabolism and tumor growth in GC. Mechanistically, WDR12 interacts with TDP43 and appears to enhance PFKFB4 expression, thereby promoting glucose metabolism. ABSTRACT Metabolic reprogramming is a hallmark of gastric cancer (GC); however, the role of transcriptional regulators in modulating glycolysis remains incompletely ...
Rutong Zhang, Dehua Liu, Xiaoxi Feng, Aoxing Cheng, Zhenye Yang, Kaiguang Zhang   +5 more
wiley   +1 more source

Impact of Gastrojejunostomy Configuration on Delayed Gastric Emptying Following Pancreaticoduodenectomy: A Single-Surgeon Retrospective Study. [PDF]

Life (Basel)
Swaid F, Masalha M, Elias R, Asadi A, Knaaneh O, Graieb M, Gorenberg M, Sheikh-Ahmad M, Shalata W, Agbarya A.   +9 more
europepmc   +1 more source

Risk stratification of clinically relevant delayed gastric emptying after pancreaticoduodenectomy. [PDF]

BMC Surg, 2023
Li TY, Qin C, Zhao BB, Yang XY, Li ZR, Wang YY, Guo JC, Han XL, Dai MH, Wang WB.   +9 more
europepmc   +1 more source

Changes in gastrointestinal motility and gut hormone secretion after Roux‐en‐Y gastric bypass and sleeve gastrectomy for individuals with severe obesity

Clinical Obesity, Volume 15, Issue 2, April 2025.
Summary Background Bariatric surgery is very effective in long‐term weight management. The present study was undertaken to investigate the short‐term effects of sleeve gastrectomy (SG) and of Roux‐en‐Y gastric bypass (RYGB) on (a) gastrointestinal (GI) motility, that is gastric emptying and oro‐cecal transit time and (b) secretion of regulatory gut ...
Jennifer A. Wilbrink, Mark van Avesaat, Simon W. Nienhuijs, Arnold Stronkhorst, Ad A. M. Masclee   +4 more
wiley   +1 more source