Results 51 to 60 of about 586,059 (333)

Magnetron plasma mediated immobilization of hyaluronic acid for the development of functional double-sided biodegradable vascular graft [PDF]

, 2020
The clinical need for vascular grafts is associated with cardiovascular diseases frequently leading to fatal outcomes. Artificial vessels based on bioresorbable polymers can replace the damaged vascular tissue or create a bypass path for blood flow while stimulating regeneration of a blood vessel in situ.
arxiv   +1 more source

KMT2A degradation is observed in decitabine‐responsive acute lymphoblastic leukemia cells

Molecular Oncology, EarlyView.
We demonstrate that decitabine (DEC) not only degrades the DNA methyltransferase DNMT1 but also the leukemic driver lysine methyltransferase KMT2A likely due to structural similarity of the DNA‐binding CXXC domains. DEC influences KMT2A downstream processes and synergizes with menin inhibitor revumenib (REV) to decrease leukemic cell proliferation, and
Luisa Brock, Lina Benzien, Sandra Lange, Maja Huehns, Alexandra Runge, Catrin Roolf, Anett Sekora, Gudrun Knuebel, Hugo Murua Escobar, Christian Junghanss, Anna Richter   +10 more
wiley   +1 more source

Prolonged graft survival in older recipient mice is determined by impaired effector T-cell but intact regulatory T-cell responses. [PDF]

PLoS ONE, 2010
Elderly organ transplant recipients represent a fast growing segment of patients on the waiting list. We examined age-dependent CD4(+) T-cell functions in a wild-type (WT) and a transgenic mouse transplant model and analyzed the suppressive function of ...
Christian Denecke, Damanpreet Singh Bedi, Xupeng Ge, Irene Kyung-Eun Kim, Anke Jurisch, Anne Weiland, Antje Habicht, Xian C Li, Stefan G Tullius   +8 more
doaj   +1 more source

Addition of Sirolimus to Cyclosporine Delays the Recovery from Delayed Graft Function but Does not Affect 1-Year Graft Function [PDF]

Journal of the American Society of Nephrology, 2004
Delayed graft function (DGF) has long been identified as one of the main correlates of poor graft survival in cadaveric renal transplantation, but the factors that affect its onset and duration are not fully elucidated. The impact of two immunosuppressive protocols on the incidence and length of DGF among kidney transplant recipients of a suboptimal ...
STALLONE, GIOVANNI, GRANDALIANO, GIUSEPPE, S. DI PAOLO, A. SCHENA, B. INFANTE, M. BATTAGLIA, P. DITONNO, L. GESUALDO, F. P. SCHENA   +8 more
openaire   +4 more sources

Financial impact of delayed graft function in kidney transplantation [PDF]

Clinical Transplantation, 2020
AbstractIncreased utilization of suboptimal organs in response to organ shortage has resulted in increased incidence of delayed graft function (DGF) after transplantation. Although presumed increased costs associated with DGF are a deterrent to the utilization of these organs, the financial burden of DGF has not been established.
Allison Dillon, Tracy J. Mayne, Weiying Wang, Kristen L. King, Kristen L. King, S. Ali Husain, S. Ali Husain, Daniel W. Kim, Daniel W. Kim, Frank A. Corvino, Sumit Mohan, Sumit Mohan, Demetra Tsapepas, Demetra Tsapepas, Demetra Tsapepas   +14 more
openaire   +3 more sources

Static and dynamic properties of the interface between a polymer brush and a melt of identical chains [PDF]

J. Chem. Phys. 124, 064902 (2006), 2005
Molecular dynamics simulations of a short-chain polymer melt between two brush-covered surfaces under shear have been performed. The end-grafted polymers which constitute the brush have the same chemical properties as the free chains in the melt and provide a soft deformable substrate.
arxiv   +1 more source

Delayed Graft Function: The AKI of Kidney Transplantation [PDF]

Nephron, 2018
With the growing wait list of individuals waiting for kidney transplantation, there has been renewed interest in the quality and function of donor organs. In particular, concern about the development of delayed allograft function (DGF) after transplantation continues to lead to the avoidance of donor organs offered to a transplant center.
openaire   +3 more sources

Patient Perceptions of Medication Therapy for Prevention of Posttraumatic Osteoarthritis Following Anterior Cruciate Ligament Injury: A Qualitative Content Analysis

Arthritis Care &Research, EarlyView.
Objective Posttraumatic osteoarthritis (PTOA) accounts for nearly 12% of osteoarthritis incidences and often occurs after anterior cruciate ligament (ACL) tear. Ensuring the uptake of preventive treatments for PTOA requires that investigators and clinicians understand factors influencing patients to seek preventive therapies.
Lily M. Waddell, Donald P. Mitchener, Kelly C. Frier, Morgan H. Jones, Elena Losina, Nick Bansback, Liana Fraenkel, Jason S. Kim, Jeffrey N. Katz, Faith Selzer, Adam Easterbrook   +10 more
wiley   +1 more source

The effect of pre-operative methylprednisolone on the incidence of delayed graft function in renal transplantation

Proceedings of Singapore Healthcare, 2016
Introduction: This study explores the effect of different corticosteroid administration timings on the incidence of slow/delayed graft function. Methods: One hundred and twelve kidney transplants from January 2011 to March 2014 were retrospectively ...
Nigel Jie Ming Fong, Petrina Yuen Wai Fan, Stephanie Man Chung Fook-Chong, Terence Yi Shern Kee   +3 more
doaj   +1 more source

Current and Future Cornea Chip Models for Advancing Ophthalmic Research and Therapeutics

Advanced Biology, EarlyView.
This review analyzes cornea chip technology as an innovative solution to corneal blindness and tissue scarcity. The examination encompasses recent developments in biomaterial design and fabrication methods replicating corneal architecture, highlighting applications in drug screening and disease modeling while addressing key challenges in mimicking ...
Minju Kim, Kanghoon Choi, Amy Lin, Jungkyu Kim   +3 more
wiley   +1 more source