Results 51 to 60 of about 6,028,935 (239)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The Association Between Early Graft Function, Donor Type and Long-Term Kidney Transplant Outcomes

Transplant International
Delayed graft function (DGF), is associated with inferior graft outcomes. Whether poor graft function without dialysis, termed slow graft function (SGF), affects outcomes is unclear.
Karthik Venkataraman, Karthik Venkataraman, Karthik Venkataraman, Georgina L. Irish, Georgina L. Irish, Georgina L. Irish, Michael G. Collins, Michael G. Collins, Michael G. Collins, Philip A. Clayton, Philip A. Clayton, Philip A. Clayton   +11 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Risk Factors of Delayed Graft Function in Patients with Kidney Transplantation

Central Asian Journal of Medical Sciences
Objective: In Mongolia, since 2006, kidney transplantation has been performed regularly, with more than 400 people having undergone this surgery.
Oyunpurev Erdenechimeg, Tuvshinbayar Javzan, Uugan-Erdene Amarbold, Od-Erdene Lkhaakhuu, Kishgee Tseren, Nyamsuren Davaajav, Bayan-Undur Dagvadorj, Erdenesaikhan Mendbayar, Ganbold Gantulga, Javkhlantugs Dondog, Zolzaya Nyamsuren, Sarantsetseg Jigjidsuren, Oyunbileg Banzragch, Batsaikhan Batsuuri, Tumurbaatar Batchuluun, Tsogjargal Burentogtokh, Enkhtuya Jambaldorj, Enkhtamir Enkhtuvshin, Ariunbold Jamba   +18 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Can baseline serum creatinine and e-GFR predict renal function outcome after augmentation cystoplasty in children?

International Brazilian Journal of Urology
Objective To assess cut-off value of creatinine and glomerular filtration rate for augmentation cystoplasty (AC) in paediatric age-group. Materials and Methods Data of all paediatric-patients (
Prempal Singh, Ankur Bansal, Virender Sekhon, Sandeep Nunia, M. S. Ansari   +4 more
doaj   +1 more source

Delayed Graft Function: The AKI of Kidney Transplantation [PDF]

Nephron, 2018
With the growing wait list of individuals waiting for kidney transplantation, there has been renewed interest in the quality and function of donor organs. In particular, concern about the development of delayed allograft function (DGF) after transplantation continues to lead to the avoidance of donor organs offered to a transplant center.
openaire   +2 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Donor Body Mass Index as a Risk Factor for Delayed Onset of Graft Function

, 2018
Delayed graft function continues to pose a significant challenge to clinicians in the context of kidney transplantation. The objective of this retrospective, 5-year analysis is to identify the parameters of beating heart donors and those of recipients ...
Juraj Miklušica, Alexander Sendrey, Ivana Dedinská, Blažej Palkoci, Denisa Osinová, Martin Vojtko, L’udovít Laca, Mariana Lajčiaková   +7 more
core   +1 more source