Results 61 to 70 of about 250,782 (299)

Very superstitious? A preliminary investigation of pigeons’ body position during a matching-to-sample task under differential and common outcome conditions. [PDF]

, 2019
The delayed matching-to-sample (DMS) task is widely employed to assess memory in a range of non-human animals. On the standard “common outcomes” (CO) DMS task, correct performance following either sample stimulus results in reinforcement. In contrast, on
Anderson, Philip, Colombo, Michael, Lord, Jessica, Scarf, Damian, van der Vliet, William   +4 more
core  

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Time resolved observation of resonant and non-resonant contributions to the nonlinear susceptibility χ(3) [PDF]

, 1978
The resonant and nonresonant part of χ(3) are distinguished by their different time behavior. The medium is coherently excited by two picosecond light pulses of defined frequency difference and the state of the system is monitored by a third properly ...
A. Laubereau, Akhmanov, Carman, Giordmaine, Heiman, Hellwarth, Laobereau, Laubereau, Levenson, Levenson, Levenson, Maker, Milam, Paillette, Penzkofer, Rado, Regnier, von der Linder, W. Kaiser, W. Zinth, Zinth   +20 more
core   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Face and object visual working memory deficits in first-episode schizophrenia correlate with multiple neurocognitive performances

General Psychiatry, 2021
Background Working memory (WM) deficit is considered a core feature and cognitive biomarker in patients with schizophrenia. Several studies have reported prominent object WM deficits in patients with schizophrenia, suggesting that visual WM in these ...
Yi Liu, Bei Zhang, Taiyong Bi, Qijie Kuang, Haijing Li, Kunlun Zong, Jingping Zhao, Yuping Ning, Shenglin She, Yingjun Zheng   +9 more
doaj   +1 more source

Multiphase MCMC sampling for parameter inference in nonlinear ordinary differential equations [PDF]

, 2018
Traditionally, ODE parameter inference relies on solving the system of ODEs and assessing fit of the estimated signal with the observations. However, nonlinear ODEs often do not permit closed form solutions. Using numerical methods to solve the equations
Husmeier, Dirk, Lazarus, Alan, Papamarkou, Theodore   +2 more
core  

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

A Trajectory-Based Approach to Multi-Session Underwater Visual SLAM Using Global Image Signatures

Journal of Marine Science and Engineering, 2019
This paper presents a multi-session monocular Simultaneous Localization and Mapping (SLAM) approach focused on underwater environments. The system is composed of three main blocks: a visual odometer, a loop detector, and an optimizer. Single session loop
Antoni Burguera Burguera, Francisco Bonin-Font   +1 more
doaj   +1 more source

Cesium‐vapor‐based delay of single photons emitted by deterministically fabricated quantum dot microlenses [PDF]

, 2019
Quantum light sources are key building blocks of photonic quantum technologies. For many applications, it is of interest to control the arrival time of single photons emitted by such quantum devices, or even to store single photons in quantum memories ...
Bremer, Lucas, Fischbach, Sarah, Heindel, Tobias, Park, Suk‐In, Reitzenstein, Stephan, Rodt, Sven, Song, Jin‐Dong   +6 more
core   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source