Results 101 to 110 of about 1,215,693 (290)

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Surgical Outcomes in Esophageal Atresia and Tracheoesophageal Fistula: A Comparison between Primary and Delayed Repair

Journal of Research in Medical Sciences, 2006
Background: The purpose of this study was to investigate outcomes of surgical repair of esophageal atresia (EA) or tracheoesophageal fistula (TEF) in newborns, with respect to incidence of death and other complications in early or late operations. ...
H Davari, R Esfandiari, M Talaei
doaj  

Delayed presentation of complete arterial transection treated with interposition graft: A case report

Trauma Case Reports, 2018
Introduction: Traumatic arterial injuries have a high degree of morbidity if left untreated. Frequently, arterial injuries are found soon after injury due to either subjective complaints or objective findings.
Gregory R. Stettler, Cenea Kemp, Franklin Wright, Erik Peltz   +3 more
doaj   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Nuclear EGFR modulation of DNA repair [PDF]

, 2011
Overexpression of the epidermal growth factor receptor (EGFR) is associated with resistance to chemotherapy and radiotherapy. EGFR involvement, in repair of radiation-induced DNA damage, is mediated by association with the catalytic subunit of DNA ...
Liccardi, G.
core  

A delayed venous repair strategy after penetrating vascular trauma

Journal of Vascular Surgery Cases and Innovative Techniques
We describe a patient with an external iliac artery and vein injury managed initially with arterial shunting and vein ligation because of hemodynamic instability.
Sahil Patel, MD, Shahabal Khan, BA, Tripti Mathur, MBBS, Camille Jackson, MD, Shahram Aarabi, MD   +4 more
doaj   +1 more source

Early versus Delayed Mobilization Post-Operative Protocols for Primary Lateral Ankle Ligament Repair: A Systematic Review and Meta-analysis

Foot & Ankle Orthopaedics, 2019
Category: Ankle, Sports, Post-op protocol Introduction/Purpose: Lateral ankle instability represents a common orthopaedic diagnosis. Nonoperative treatment through focused physical therapy provides satisfactory results in most patients.
Matthew L. Vopat MD, Armin Tarakemeh BA, Brandon Morris MD, Maaz Hassan BS, Pat Garvin BA, Rosalee Zackula MA, Scott Mullen MD, Paul Schroeppel MD, Bryan G. Vopat MD   +8 more
doaj   +1 more source

ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function

FEBS Open Bio, EarlyView.
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley, Luke W. Molesworth, Nethma H. Waduge, Fahimeh Eskandari, Peter R. Boag, Gregory M. Davis   +5 more
wiley   +1 more source

Cells expressing murine RAD52 splice variants favor sister chromatid repair [PDF]

, 2006
The RAD52 gene is essential for homologous recombination in the yeast Saccharomyces cerevisiae. RAD52 is the archetype in an epistasis group of genes essential for DNA damage repair.
Freeman, TC, Savitzky, MH, Sunjevaric, [No Value], Rothstein, R, Marrero, VA, Thorpe, PH   +5 more
core   +1 more source

Does thoracoscopic repair of type C esophageal atresia require emergency treatment?

BMC Surgery
Background Thoracoscopic repair of esophageal atresia (EA) with tracheoesophageal fistula (TEF) has been performed with increasing frequency. Although many children have underwent surgery within three days after birth, the optimal timing for operation ...
Chen Wang, Guoqing Cao, Kang Li, Yang Zhang, Mengxin Zhang, Xi Zhang, Shuiqing Chi, Yu Guo, Shuai Li, Shao-tao Tang   +9 more
doaj   +1 more source